Tan Zhuomin, Huang Hui, Sun Wenyan, Li Ya, Jia Yinnong
Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, China.
Front Mol Biosci. 2022 Aug 26;9:966007. doi: 10.3389/fmolb.2022.966007. eCollection 2022.
Tumors are the leading cause of death all over the world, among which ovarian cancer ranks the third in gynecological malignancies. The current treatment for ovarian cancer is liable to develop chemotherapy resistance and high recurrence rate, in which a new strategy is demanded. Ferroptosis, a newly discovered manner of regulatory cell death, is shown to be induced by massive iron-dependent accumulation of lipid reactive oxygen species. With the in-depth study of ferroptosis, its associated mechanism with various tumors is gradually elucidated, including ovarian tumor, which probably promotes the application of ferroptosis in treating ovarian cancer. To this end, this review will focus on the history and current research progress of ferroptosis, especially its regulation mechanism, and its potential application as a novel treatment strategy for ovarian cancer.
肿瘤是全球主要的死亡原因，其中卵巢癌在妇科恶性肿瘤中排名第三。目前卵巢癌的治疗容易产生化疗耐药性且复发率高，因此需要一种新的治疗策略。铁死亡是一种新发现的调节性细胞死亡方式，由大量铁依赖性脂质活性氧积累诱导产生。随着对铁死亡研究的深入，其与包括卵巢肿瘤在内的各种肿瘤的相关机制逐渐被阐明，这可能会促进铁死亡在卵巢癌治疗中的应用。为此，本综述将重点关注铁死亡的历史和当前研究进展，尤其是其调控机制，以及作为卵巢癌新治疗策略的潜在应用。
