隐球菌抗原检测假阳性与颈椎前间隙脓肿
False-positive cryptococcal antigen test and cervical prevertebral abscess.
作者信息
MacKinnon S, Kane J G, Parker R H
出版信息
JAMA. 1978 Oct 27;240(18):1982-3.
PMID:357768
Abstract
A false-positive latex agglutination test for cryptococcal antigen occurred in a patient with a cervical prevertebral abscess and vertebral osteomyelitis caused by Klebsiella pneumoniae. Using a commercial latex agglutination test kit, a cryptococcal antigen titer of 1:32 was found in the CSF, but no cryptococcal antigen was found when the CSF was retested at a reference laboratory. The false-positive test resulted in unnecessary therapy with amphotericin B and delay in appropriate diagnostic studies and therapy.
摘要
一名患有颈椎前脓肿和由肺炎克雷伯菌引起的椎体骨髓炎的患者，其隐球菌抗原乳胶凝集试验出现假阳性。使用商用乳胶凝集试验试剂盒，在脑脊液中发现隐球菌抗原滴度为1:32，但当脑脊液在参考实验室重新检测时未发现隐球菌抗原。假阳性检测导致了不必要的两性霉素B治疗，并延误了适当的诊断研究和治疗。
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