Oncological Department, Sant'Andrea Hospital, University Sapienza in Rome, Rome, Italy.
Oncological Department, University Sapienza in Rome, Rome, Italy.
Radiol Oncol. 2022 Aug 14;56(3):285-291. doi: 10.2478/raon-2022-0022.
Electrochemotherapy (ECT) is a minimally invasive and safe treatment gaining positive and long-lasting antitumoral results that are receiving the attention of the scientific community. It is a local treatment that combines the use of electroporation and the administration of cytotoxic drugs to induce cell death in the target tissue. ECT is largely used for the treatment of cutaneous and subcutaneous lesions, and good results have been reported for the treatment of deep visceral tumors. The latest literature review is provided. Moreover, in line with its development for the treatment of visceral tumors in this article, we describe a novel approach of ECT: endoscopic treatment of colorectal cancer. Endoscopic ECT application was combined with systemic chemotherapy in the treatment of obstructing rectal cancer without prospective surgery. A good response after ECT was described: concentric involvement of the rectum was reduced, and no stenosing lesions were detected.
Clinical studies have demonstrated that ECT is a very effective treatment for tumors of different histologic types and localizations. Endoscopic treatment for gastrointestinal cancer is an innovative application of ECT. The combination of systemic treatment and ECT was safe and highly effective in the treatment of colorectal cancer, especially when obstructive, giving the patient a significant gain in quality of life.
电化疗（ECT）是一种微创且安全的治疗方法，已取得积极且持久的抗肿瘤效果，引起了科学界的关注。它是一种局部治疗方法，结合使用电穿孔和细胞毒性药物，以诱导目标组织中的细胞死亡。ECT 主要用于治疗皮肤和皮下病变，并且对于治疗深部内脏肿瘤已经有了良好的效果。本文提供了最新的文献综述。此外，根据ECT 治疗内脏肿瘤的发展，我们描述了一种 ECT 的新方法：结直肠的内镜治疗。将内镜 ECT 应用与全身化疗联合用于治疗无预期手术的阻塞性直肠癌。描述了 ECT 后的良好反应：直肠的同心受累减少，未发现狭窄性病变。
临床研究表明，ECT 是一种对不同组织学类型和定位的肿瘤非常有效的治疗方法。胃肠道癌症的内镜治疗是 ECT 的一种创新应用。全身治疗与 ECT 的联合应用在治疗结直肠癌，尤其是在梗阻性病例中，是安全且高效的，可显著提高患者的生活质量。
