Campana Luca G, Daud Adil, Lancellotti Francesco, Arroyo Julio P, Davalos Rafael V, Di Prata Claudia, Gehl Julie
Department of Surgery, Manchester University NHS Foundation Trust, Oxford Rd., Manchester M13 9WL, UK.
Department of Medicine, University of California, 550 16 Street, San Francisco, CA 94158, USA.
Cancers (Basel). 2023 Jun 25;15(13):3340. doi: 10.3390/cancers15133340.
The 4th World Congress of Electroporation (Copenhagen, 9-13 October 2022) provided a unique opportunity to convene leading experts in pulsed electric fields (PEF). PEF-based therapies harness electric fields to produce therapeutically useful effects on cancers and represent a valuable option for a variety of patients. As such, irreversible electroporation (IRE), gene electrotransfer (GET), electrochemotherapy (ECT), calcium electroporation (Ca-EP), and tumour-treating fields (TTF) are on the rise. Still, their full therapeutic potential remains underappreciated, and the field faces fragmentation, as shown by parallel maturation and differences in the stages of development and regulatory approval worldwide. This narrative review provides a glimpse of PEF-based techniques, including key mechanisms, clinical indications, and advances in therapy; finally, it offers insights into current research directions. By highlighting a common ground, the authors aim to break silos, strengthen cross-functional collaboration, and pave the way to novel possibilities for intervention. Intriguingly, beyond their peculiar mechanism of action, PEF-based therapies share technical interconnections and multifaceted biological effects (e.g., vascular, immunological) worth exploiting in combinatorial strategies.
第四届电穿孔世界大会（2022年10月9日至13日，哥本哈根）为召集脉冲电场（PEF）领域的顶尖专家提供了一个独特的契机。基于PEF的疗法利用电场对癌症产生治疗性有益效果，是各类患者的一个有价值的选择。因此，不可逆电穿孔（IRE）、基因电转染（GET）、电化学疗法（ECT）、钙电穿孔（Ca-EP）和肿瘤治疗电场（TTF）正在兴起。然而，它们的全部治疗潜力仍未得到充分认识，并且该领域面临着碎片化问题，全球范围内发展阶段和监管批准的平行成熟及差异就表明了这一点。这篇叙述性综述简要介绍了基于PEF的技术，包括关键机制、临床适应症和治疗进展；最后，它提供了对当前研究方向的见解。通过强调共同点，作者旨在打破壁垒，加强跨职能合作，并为新的干预可能性铺平道路。有趣的是，除了其独特的作用机制外，基于PEF的疗法还具有技术上的相互联系和多方面的生物学效应（如血管、免疫方面），值得在联合策略中加以利用。
