Bondok A A
Acta Neuropathol. 1987;72(4):335-40. doi: 10.1007/BF00687264.
Glycogen accumulation in the Clarke's nucleus neuropil of young adult rats whose sciatic nerves were crushed in the first postnatal day was investigated with the electron microscope. Glycogen was observed in synaptic boutons and in small myelinated axons. In some terminals, glycogen accumulated in membrane-bound structures resembling mitochondria and formed large multigranular bodies which were entirely separated from the axoplasm. The multigranular body reached the size of 1.3 micron. Glycogen was present as single beta particles of about 25-40 nm in diameter and in aggregations of large alpha clusters. The astrocytic glycogen distribution was almost similar to that of the control specimens. Glycogen was not observed in other glial cells. It is probable that glycogen accumulation in synaptic terminals of partially deafferentiated Clarke's nucleus may result from impaired glycolysis due to deficient resupply of the distal axon with glycolytic enzymes caused by a defect in axoplasmic transport from the hypoplastic sensory neuronal perikarya.
用电子显微镜研究了出生后第一天坐骨神经被挤压的成年幼鼠克拉克核神经毡中的糖原积累情况。在突触小体和小的有髓轴突中观察到糖原。在一些终末中，糖原积聚在类似线粒体的膜结合结构中，并形成了与轴浆完全分离的大型多颗粒体。多颗粒体的大小达到1.3微米。糖原以直径约25 - 40纳米的单个β颗粒和大的α簇聚集体形式存在。星形胶质细胞中糖原的分布与对照标本几乎相似。在其他神经胶质细胞中未观察到糖原。部分去传入的克拉克核突触终末中糖原积累，可能是由于发育不全的感觉神经元胞体的轴浆运输缺陷，导致远端轴突糖酵解酶再供应不足，从而引起糖酵解受损所致。
