Bondok A A, Sansone F M
Exp Neurol. 1984 Nov;86(2):322-30. doi: 10.1016/0014-4886(84)90190-0.
The sciatic nerve of newborn rats (less than or equal to 16 h old) was crushed with a watchmaker forceps. During the first 4 weeks after the injury, examination of ipsilateral L4 through L6 dorsal root ganglia, their dorsal nerve roots, and the dorsal funiculus revealed the presence of degenerating myelin and axons. Chromatolysis was not observed. In the spinal cord, the degenerating argyrophilia was restricted to the medial part of the dorsal funiculus (fasciculus gracilis). This is interpreted as transganglionic degeneration of the central processes of the pseudounipolar cells. Twelve weeks after nerve crush, there was a noticeable reduction in the size of the leg, foot, and muscles innervated by the sciatic nerve as well as a substantial loss (P less than 0.001) of neurons and myelinated axons in ipsilateral spinal ganglia and their dorsal nerve roots. The reduction was most prominent among the larger sensory neurons (greater than 40 microns) and the larger myelinated axons. A total loss of about 60% of sensory neurons was found in the L4 through L6 spinal ganglia. About 58 and 64% of the myelinated axons were lost in L4 and L5 dorsal roots, respectively. The remaining perikarya and dorsal root axons were hypoplastic.
用钟表匠镊子夹伤新生大鼠（小于或等于16小时龄）的坐骨神经。在损伤后的前4周，对同侧L4至L6背根神经节、其背根神经以及背索进行检查，发现存在变性的髓鞘和轴突。未观察到染色质溶解。在脊髓中，变性的嗜银性仅限于背索（薄束）的内侧部分。这被解释为假单极细胞中枢突的跨节变性。神经挤压伤12周后，由坐骨神经支配的腿部、足部和肌肉的大小明显减小，同侧脊髓神经节及其背根神经中的神经元和有髓轴突大量丢失（P<0.001）。这种减少在较大的感觉神经元（大于40微米）和较大的有髓轴突中最为明显。在L4至L6脊髓神经节中发现约60%的感觉神经元完全丢失。L4和L5背根中分别约有58%和64%的有髓轴突丢失。其余的胞体和背根轴突发育不全。
