Translational Oncology Research Unit, Department of Research, Diagnosis and Innovative Technologies, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Division of Medical Oncology 2, IRCCS Regina Elena National Cancer Institute, Rome, Italy; Clinical Trial Center, Biostatistics and Bioinformatics Unit, Department of Research, Diagnosis and Innovative Technologies, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Biochim Biophys Acta Rev Cancer. 2022 Jul;1877(4):188756. doi: 10.1016/j.bbcan.2022.188756. Epub 2022 Jun 28.
The transcriptional regulators YAP and TAZ are involved in numerous physiological processes including organ development, growth, immunity and tissue regeneration. YAP and TAZ dysregulation also contribute to tumorigenesis, thereby making them attractive cancer therapeutic targets. Arbitrarily, YAP and TAZ are often considered as a single protein, and are referred to as YAP/TAZ in most studies. However, increasing experimental evidences documented that YAP and TAZ perform both overlapping and distinct functions in several physiological and pathological processes. In addition to regulating distinct processes, YAP and TAZ are also regulated by distinct upstream cues. The aim of the review is to describe the distinct roles of YAP and TAZ focusing particularly on cancer. Therapeutic strategies targeting either YAP and TAZ proteins or only one of them should be carefully evaluated. Selective targeting of YAP or TAZ may in fact impair different pathways and determine diverse clinical outputs.
转录调节因子 YAP 和 TAZ 参与许多生理过程，包括器官发育、生长、免疫和组织再生。YAP 和 TAZ 的失调也有助于肿瘤发生，因此它们成为有吸引力的癌症治疗靶点。任意地，YAP 和 TAZ 通常被认为是一种单一的蛋白质，并且在大多数研究中被称为 YAP/TAZ。然而，越来越多的实验证据表明，YAP 和 TAZ 在几种生理和病理过程中既具有重叠的功能，也具有独特的功能。除了调节不同的过程外，YAP 和 TAZ 还受到不同的上游线索的调节。本综述的目的是描述 YAP 和 TAZ 的独特作用，特别是在癌症方面。针对 YAP 和 TAZ 蛋白或其中之一的治疗策略应仔细评估。选择性靶向 YAP 或 TAZ 实际上可能会破坏不同的途径，并决定不同的临床结果。
