孕期母体钙摄入量与儿童期血压：九州冲绳母婴健康研究。
Maternal calcium intake during pregnancy and childhood blood pressure: the Kyushu Okinawa Maternal and Child Health Study.
机构信息
Department of Epidemiology and Public Health, Ehime University Graduate School of Medicine, Ehime, Japan; Integrated Medical and Agricultural School of Public Health, Ehime University, Ehime, Japan; Research Promotion Unit, Translation Research Center, Ehime University Hospital, Ehime, Japan; Center for Data Science, Ehime University, Ehime, Japan.
Department of Epidemiology and Public Health, Ehime University Graduate School of Medicine, Ehime, Japan; Integrated Medical and Agricultural School of Public Health, Ehime University, Ehime, Japan; Research Promotion Unit, Translation Research Center, Ehime University Hospital, Ehime, Japan; Center for Data Science, Ehime University, Ehime, Japan.
出版信息
Ann Epidemiol. 2022 Sep;73:17-21. doi: 10.1016/j.annepidem.2022.06.035. Epub 2022 Jun 29.
PURPOSE
Evidence regarding the relationship between maternal calcium intake during pregnancy and childhood blood pressure is limited and inconsistent. The present prebirth cohort study examined this issue in Japanese children aged 6 years.
METHODS
Subjects were 854 mother-child pairs. Maternal intake during pregnancy was assessed with a validated diet history questionnaire. A research technician measured systolic and diastolic blood pressures at home in children aged 6 years using an electronic sphygmomanometer. Analysis of covariance was used to calculate adjusted means of systolic and diastolic blood pressures according to maternal calcium intake during pregnancy.
RESULTS
Maternal calcium intake during pregnancy was not related to systolic blood pressure in children. On the other hand, compared with children of mothers whose calcium intake during pregnancy was in the lowest quartile, those of mothers whose calcium intake during pregnancy was in the highest quartile had 2.8 mmHg lower adjusted mean diastolic blood pressure (95% confidence interval: 0.3-5.3 mmHg, P for trend = .009).
CONCLUSIONS
Higher maternal calcium intake during pregnancy may be associated with a decrease in diastolic, but not systolic, blood pressure in Japanese children aged 6 years.
目的
关于孕妇孕期钙摄入量与儿童血压之间关系的证据有限且不一致。本产前队列研究在 6 岁日本儿童中探讨了这一问题。
方法
研究对象为 854 对母婴。孕期钙摄入量通过经过验证的饮食史问卷进行评估。研究人员在家中使用电子血压计为 6 岁儿童测量收缩压和舒张压。采用协方差分析，根据孕妇孕期钙摄入量计算收缩压和舒张压的调整均值。
结果
孕妇孕期钙摄入量与儿童收缩压无关。另一方面，与孕期钙摄入量最低四分位数的儿童相比，孕期钙摄入量最高四分位数的儿童的调整平均舒张压低 2.8mmHg（95%置信区间：0.3-5.3mmHg，趋势 P 值=0.009）。
结论
孕妇孕期钙摄入量较高可能与 6 岁日本儿童舒张压降低相关，而非收缩压。
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