Bakker Rachel, Rifas-Shiman Sheryl L, Kleinman Ken P, Lipshultz Steven E, Gillman Matthew W
The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands.
Am J Epidemiol. 2008 Dec 15;168(12):1374-80. doi: 10.1093/aje/kwn258. Epub 2008 Oct 22.
A previous analysis of the Project Viva cohort (eastern Massachusetts, 1999-2002 recruitment) found an association between higher second-trimester supplemental maternal calcium intake and lower systolic blood pressure in offspring at 6 months. The authors analyzed 5,527 systolic blood pressure measurements from 1,173 mother-child pairs from this same cohort when the children were aged 3 years. They estimated the change in offspring blood pressure for a 500-mg difference in maternal total, dietary-only, and supplemental-only calcium intake during the first 2 trimesters of pregnancy. Mean daily total calcium intake was 1,311 mg (standard deviation, 421) in the first trimester and 1,440 mg (standard deviation, 386) in the second trimester. Mean systolic blood pressure of the offspring at age 3 years was 92.1 mm Hg (standard deviation, 10.3). None of the maternal calcium intake measures during the first and second trimesters was associated with systolic blood pressure in the offspring. For example, for each 500-mg increment in maternal total elemental calcium intake in the second trimester, child's 3-year systolic blood pressure was 0.1 mm Hg lower (95% confidence interval: -0.9, 0.6). Maternal calcium intake during pregnancy was not associated with offspring blood pressure at the age of 3 years.
先前对“活力项目”队列（1999 - 2002年在马萨诸塞州东部招募）的一项分析发现，孕中期母亲补充钙摄入量较高与后代6个月时收缩压较低之间存在关联。作者分析了来自同一队列的1173对母婴在孩子3岁时的5527次收缩压测量值。他们估计了孕期前两季度母亲总钙摄入量、仅膳食钙摄入量和仅补充钙摄入量相差500毫克时后代血压的变化。孕早期平均每日总钙摄入量为1311毫克（标准差421），孕中期为1440毫克（标准差386）。后代3岁时的平均收缩压为92.1毫米汞柱（标准差10.3）。孕早期和孕中期母亲的任何钙摄入量测量值均与后代的收缩压无关。例如，孕中期母亲总元素钙摄入量每增加500毫克，孩子3岁时的收缩压降低0.1毫米汞柱（95%置信区间：-0.9，0.6）。孕期母亲的钙摄入量与孩子3岁时的血压无关。
