Department of Pediatrics, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, Guangdong, China.
Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangzhou, 510150, Guangdong, China.
Sci Rep. 2022 Jul 1;12(1):11119. doi: 10.1038/s41598-022-14432-2.
With the increase in extremely low birth weight (ELBW) infants, their outcome attracted worldwide attention. However, in China, the related studies are rare. The hospitalized records of ELBW infants discharged from twenty-six neonatal intensive care units in Guangdong Province of China during 2008-2017 were analyzed. A total of 2575 ELBW infants were enrolled and the overall survival rate was 55.11%. From 2008 to 2017, the number of ELBW infants increased rapidly from 91 to 466, and the survival rate improved steadily from 41.76% to 62.02%. Increased survival is closely related to birth weight (BW), regional economic development, and specialized hospital. The incidence of complications was neonatal respiratory distress syndrome (85.2%), oxygen dependency at 28 days (63.7%), retinopathy of prematurity (39.3%), intraventricular hemorrhage (29.4%), necrotizing enterocolitis (12.0%), and periventricular leukomalacia (8.0%). Among the 1156 nonsurvivors, 90.0% of infants died during the neonatal period (≤ 28 days). A total of 768 ELBW infants died after treatment withdrawal, for reasons of economic and/or poor outcome. The number of ELBW infants is increasing in Guangdong Province of China, and the overall survival rate is improving steadily.
随着极低出生体重儿（ELBW）的增加，其结局引起了全世界的关注。然而，在中国，相关研究很少。分析了 2008-2017 年期间中国广东省 26 个新生儿重症监护病房出院的 ELBW 婴儿的住院记录。共纳入 2575 例 ELBW 婴儿，总体存活率为 55.11%。2008 年至 2017 年，ELBW 婴儿的数量从 91 例迅速增加到 466 例，存活率从 41.76%稳步提高到 62.02%。存活率的提高与出生体重（BW）、区域经济发展和专科医院密切相关。并发症的发生率为新生儿呼吸窘迫综合征（85.2%）、28 天吸氧依赖（63.7%）、早产儿视网膜病变（39.3%）、脑室周围出血（29.4%）、坏死性小肠结肠炎（12.0%）和脑室周围白质软化（8.0%）。在 1156 例死亡患儿中，90.0%的患儿在新生儿期（≤28 天）死亡。共有 768 例 ELBW 婴儿因经济和/或预后不良而放弃治疗后死亡。广东省 ELBW 婴儿数量呈上升趋势，总体存活率稳步提高。
