Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe University, Theodor-Stern Kai 7, 60590, Frankfurt, Germany.
Sci Rep. 2022 Jul 1;12(1):11116. doi: 10.1038/s41598-022-15287-3.
The ongoing SARS-CoV-2 pandemic is characterized by poor outcome and a high mortality especially in the older patient cohort. Up to this point there is a lack of data characterising COVID-19 patients in Germany admitted to intensive care (ICU) vs. non-ICU patients. German Reimbursement inpatient data covering the period in Germany from January 1st, 2020 to December 31th, 2021 were analyzed. 561,379 patients were hospitalized with COVID-19. 24.54% (n = 137,750) were admitted to ICU. Overall hospital mortality was 16.69% (n = 93,668) and 33.36% (n = 45,947) in the ICU group. 28.66% (n = 160,881) of all patients suffer from Cardiac arrhythmia and 17.98% (n = 100,926) developed renal failure. Obesity showed an odds-ratio ranging from 0.83 (0.79-0.87) for WHO grade I to 1.13 (1.08-1.19) for grade III. Mortality-rates peaked in April 2020 and January 2021 being 21.23% (n = 4539) and 22.99% (n = 15,724). A third peak was observed November and December 2021 (16.82%, n = 7173 and 16.54%, n = 9416). Hospitalized COVID-19 patient mortality in Germany is lower than previously shown in other studies. 24.54% of all patients had to be treated in the ICU with a mortality rate of 33.36%. Congestive heart failure was associated with a higher risk of death whereas low grade obesity might have a protective effect on patient survival. High admission numbers are accompanied by a higher mortality rate.
目前，关于德国重症监护病房（ICU）与非 ICU 收治的 COVID-19 患者的数据尚不清楚。本研究分析了德国从 2020 年 1 月 1 日至 2021 年 12 月 31 日期间的医保住院数据。共 561379 例 COVID-19 患者住院，其中 24.54%（n=137750）被收入 ICU。总体院内死亡率为 16.69%（n=93668），ICU 组死亡率为 33.36%（n=45947）。所有患者中有 28.66%（n=160881）患有心律失常，17.98%（n=100926）发生肾衰竭。肥胖的 OR 值范围从 WHO 1 级的 0.83（0.79-0.87）到 3 级的 1.13（1.08-1.19）。死亡率在 2020 年 4 月和 2021 年 1 月达到峰值，分别为 21.23%（n=4539）和 22.99%（n=15724）。2021 年 11 月和 12 月出现第三次高峰，死亡率分别为 16.82%（n=7173）和 16.54%（n=9416）。德国 COVID-19 住院患者的死亡率低于之前其他研究报道。所有患者中有 24.54%需要在 ICU 治疗，死亡率为 33.36%。充血性心力衰竭与死亡风险增加相关，而轻度肥胖可能对患者生存有保护作用。高入院人数伴随着更高的死亡率。
