Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Pediatr Res. 2023 Feb;93(3):492-502. doi: 10.1038/s41390-022-02162-0. Epub 2022 Jul 1.
Lower respiratory tract infections (LRTIs) are a leading cause of morbidity and mortality in children. The ability of healthcare providers to diagnose and prognose LRTIs in the pediatric population remains a challenge, as children can present with similar clinical features regardless of the underlying pathogen or ultimate severity. Metabolomics, the large-scale analysis of metabolites and metabolic pathways offers new tools and insights that may aid in diagnosing and predicting the outcomes of LRTIs in children. This review highlights the latest literature on the clinical utility of metabolomics in providing care for children with bronchiolitis, pneumonia, COVID-19, and sepsis. IMPACT: This article summarizes current metabolomics approaches to diagnosing and predicting the course of pediatric lower respiratory infections. This article highlights the limitations to current metabolomics research and highlights future directions for the field.
下呼吸道感染（LRTIs）是导致儿童发病和死亡的主要原因。医疗保健提供者诊断和预测儿科人群中 LRTIs 的能力仍然是一个挑战，因为无论潜在病原体或最终严重程度如何，儿童的临床表现都可能相似。代谢组学是对代谢物和代谢途径的大规模分析，提供了新的工具和见解，可能有助于诊断和预测儿童 LRTIs 的结果。本综述重点介绍了代谢组学在毛细支气管炎、肺炎、COVID-19 和脓毒症患儿治疗中的临床应用的最新文献。 影响：本文总结了目前用于诊断和预测儿科下呼吸道感染病程的代谢组学方法。本文强调了当前代谢组学研究的局限性，并突出了该领域的未来方向。
