检测呼出气中的挥发性硫化合物（VSCs）作为口腔鳞状细胞癌的一种潜在诊断方法。
Detection of volatile sulfur compounds (VSCs) in exhaled breath as a potential diagnostic method for oral squamous cell carcinoma.
机构信息
Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, 101 Daehakro, Jongnogu, Seoul, 03080, Korea.
Department of Oral and Maxillofacial Surgery, Busan Paik Hospital, Inje University, Bokji-ro 75, Busanjin-gu, Busan, 47392, Korea.
出版信息
BMC Oral Health. 2022 Jul 1;22(1):268. doi: 10.1186/s12903-022-02301-3.
BACKGROUND
Oral squamous cell carcinoma causes a significant proportion of global cancer morbidity and mortality. The aim of this study is to investigate whether the exhaled breath test can be a new, non-invasive, and effective method for diagnosing oral squamous cell carcinoma.
METHODS
A comparative analysis of exhaled breath between patients with oral squamous cell carcinoma (OSCC) and healthy controls (HC) was performed with the Twin Breasor II™, a simple gas chromatography system.
RESULTS
Both hydrogen sulfide (HS) and methyl mercaptan (ChSH) were significantly higher in the OSCC group than in the HC group. The total sulfur concentration was also higher in the OSCC group, but there was no significant difference in the ratio of ChSH to HS between the two groups. Using logistic regression, we constructed a new variable with an area under the curve (AUC) of 0.740, 68.0% sensitivity, and 72.0% specificity.
CONCLUSIONS
Exhaled gas analysis via simple gas chromatography can potentially serve as an accessory non-invasive method for OSCC diagnosis.
背景
口腔鳞状细胞癌导致了相当一部分的全球癌症发病率和死亡率。本研究旨在探讨呼气试验是否可以成为一种新的、非侵入性和有效的口腔鳞状细胞癌诊断方法。
方法
采用 Twin Breasor II™ 简单气相色谱系统对口腔鳞状细胞癌（OSCC）患者和健康对照（HC）的呼气进行对比分析。
结果
OSCC 组的硫化氢（HS）和甲硫醇（ChSH）均明显高于 HC 组。OSCC 组的总硫浓度也较高，但两组间 ChSH 与 HS 的比值无显著差异。使用逻辑回归，我们构建了一个新的变量，其曲线下面积（AUC）为 0.740，灵敏度为 68.0%，特异性为 72.0%。
结论
通过简单气相色谱的呼气气体分析可能可以作为 OSCC 诊断的一种辅助性非侵入性方法。
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