藏红花和视网膜神经退行性疾病：化学成分的相关性。
Saffron and retinal neurodegenerative diseases: Relevance of chemical composition.
机构信息
Hortus Novus srl, Canistro, Italy.
Department of Physical and Chemical Sciences, University of L'Aquila, Coppito, Italy.
出版信息
J Anat. 2023 Aug;243(2):265-273. doi: 10.1111/joa.13722. Epub 2022 Jul 2.
Abstract
Saffron is an ancient spice largely used in traditional medicine. It has been found to be effective in treatment of retinal neurodegenerative diseases like age-related macular degeneration and Stargardt. In the present manuscript, it is shown that saffron's neuroprotective power is strongly related to the bioactivity of all its chemical components. Nuclear magnetic resonance spectroscopy and "in vitro" experiments confirm the relevance of crocins for saffron efficacy. These results underline the importance of strictly defining the chemical composition of the natural compounds in saffron to optimize their effectiveness in the treatment of diseases.
摘要
藏红花是一种古老的香料，在传统医学中被广泛使用。它已被发现对视网膜神经退行性疾病如年龄相关性黄斑变性和斯特格德氏病有效。在本手稿中，表明藏红花的神经保护能力与其所有化学成分的生物活性密切相关。核磁共振波谱和“体外”实验证实了藏红花酸对于藏红花功效的相关性。这些结果强调了严格定义藏红花中天然化合物的化学成分以优化其在治疗疾病中的有效性的重要性。
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