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The P2X7 Receptor: A Promising Pharmacological Target in Diabetic Retinopathy.P2X7 受体：糖尿病视网膜病变有前景的药物靶点。
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Saffron: A potential drug-supplement for severe acute respiratory syndrome coronavirus (COVID) management.藏红花：一种用于严重急性呼吸综合征冠状病毒（COVID）治疗的潜在药物补充剂。
Heliyon. 2021 May;7(5):e07068. doi: 10.1016/j.heliyon.2021.e07068. Epub 2021 May 14.
3
Investigation on penetration of saffron components through lipid bilayer bound to spike protein of SARS-CoV-2 using steered molecular dynamics simulation.利用 steer 分子动力学模拟研究藏红花成分通过与 SARS-CoV-2 刺突蛋白结合的脂质双层的渗透情况。
Heliyon. 2020 Dec;6(12):e05681. doi: 10.1016/j.heliyon.2020.e05681. Epub 2020 Dec 13.
4
Saffron: Chemical Composition and Neuroprotective Activity.藏红花：化学成分和神经保护活性。
Molecules. 2020 Nov 29;25(23):5618. doi: 10.3390/molecules25235618.
5
Medicinal plants and natural products as neuroprotective agents in age-related macular degeneration.药用植物和天然产物作为年龄相关性黄斑变性的神经保护剂
Neural Regen Res. 2020 Dec;15(12):2207-2216. doi: 10.4103/1673-5374.284978.
6
Targeting the P2X7 Receptor in Age-Related Macular Degeneration.靶向年龄相关性黄斑变性中的P2X7受体
Vision (Basel). 2017 Mar 31;1(2):11. doi: 10.3390/vision1020011.
7
Antioxidant Saffron and Central Retinal Function in ABCA4-Related Stargardt Macular Dystrophy.抗氧化藏红花与 ABCA4 相关性渗出性年龄相关性黄斑变性的中心视网膜功能。
Nutrients. 2019 Oct 15;11(10):2461. doi: 10.3390/nu11102461.
8
Saffron: A Multitask Neuroprotective Agent for Retinal Degenerative Diseases.藏红花：一种用于视网膜退行性疾病的多任务神经保护剂。
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Targeting P2X7 receptors as a means for treating retinal disease.以 P2X7 受体为靶点治疗视网膜疾病。
Drug Discov Today. 2019 Aug;24(8):1598-1605. doi: 10.1016/j.drudis.2019.03.029. Epub 2019 Apr 4.
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Saffron ( L.) in Ocular Diseases: A Narrative Review of the Existing Evidence from Clinical Studies.藏红花（ L.）在眼部疾病中的应用：临床研究现有证据的叙述性综述。
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藏红花和视网膜神经退行性疾病：化学成分的相关性。

Saffron and retinal neurodegenerative diseases: Relevance of chemical composition.

机构信息

Hortus Novus srl, Canistro, Italy.

Department of Physical and Chemical Sciences, University of L'Aquila, Coppito, Italy.

出版信息

J Anat. 2023 Aug;243(2):265-273. doi: 10.1111/joa.13722. Epub 2022 Jul 2.

DOI:10.1111/joa.13722
PMID:35778985
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10335369/
Abstract

Saffron is an ancient spice largely used in traditional medicine. It has been found to be effective in treatment of retinal neurodegenerative diseases like age-related macular degeneration and Stargardt. In the present manuscript, it is shown that saffron's neuroprotective power is strongly related to the bioactivity of all its chemical components. Nuclear magnetic resonance spectroscopy and "in vitro" experiments confirm the relevance of crocins for saffron efficacy. These results underline the importance of strictly defining the chemical composition of the natural compounds in saffron to optimize their effectiveness in the treatment of diseases.

摘要

藏红花是一种古老的香料，在传统医学中被广泛使用。它已被发现对视网膜神经退行性疾病如年龄相关性黄斑变性和斯特格德氏病有效。在本手稿中，表明藏红花的神经保护能力与其所有化学成分的生物活性密切相关。核磁共振波谱和“体外”实验证实了藏红花酸对于藏红花功效的相关性。这些结果强调了严格定义藏红花中天然化合物的化学成分以优化其在治疗疾病中的有效性的重要性。