Aston University, School of Life and Health Sciences, Aston Triangle, Birmingham B4 7ET, UK.
Aston Medical Research Institute, Aston Medical School, Aston University, Birmingham B4 7ET, UK.
Nutrients. 2019 Mar 18;11(3):649. doi: 10.3390/nu11030649.
Saffron ( L.) and its main constituents, i.e., crocin and crocetin, are natural carotenoid compounds, which have been reported to possess a wide spectrum of properties and induce pleiotropic anti-inflammatory, anti-oxidative, and neuroprotective effects. An increasing number of experimental, animal, and human studies have investigated the effects and mechanistic pathways of these compounds in order to assess their potential therapeutic use in ocular diseases (e.g., in age related macular degeneration, glaucoma, and diabetic maculopathy). This narrative review presents the key findings of published clinical studies that examined the effects of saffron and/or its constituents in the context of ocular disease, as well as an overview of the proposed underlying mechanisms mediating these effects.
藏红花（L.）及其主要成分，即藏红花酸和藏红花酸，是天然类胡萝卜素化合物，据报道具有广泛的特性，并具有多效抗炎、抗氧化和神经保护作用。越来越多的实验、动物和人体研究调查了这些化合物的作用和机制途径，以评估它们在眼部疾病（例如年龄相关性黄斑变性、青光眼和糖尿病性黄斑病变）中的潜在治疗用途。本叙述性综述介绍了已发表的临床研究的主要发现，这些研究检查了藏红花及其成分在眼部疾病背景下的作用，以及介导这些作用的潜在机制概述。
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