Hortus Novus srl, via Campo Sportivo 2, 67050 Canistro, Italy.
Department of Phyisical and Chemical Sciences, University of L'Aquila, Via Vetoio, 67100 Coppito, Italy.
Molecules. 2020 Nov 29;25(23):5618. doi: 10.3390/molecules25235618.
L. belongs to the Iridaceae family and it is commonly known as saffron. The different cultures together with the geoclimatic characteristics of the territory determine a different chemical composition that characterizes the final product. This is why a complete knowledge of this product is fundamental, from which more than 150 chemical compounds have been extracted from, but only about one third of them have been identified. The chemical composition of saffron has been studied in relation to its efficacy in coping with neurodegenerative retinal diseases. Accordingly, experimental results provide evidence of a strict correlation between chemical composition and neuroprotective capacity. We found that saffron's ability to cope with retinal neurodegeneration is related to: (1) the presence of specific crocins and (2) the contribution of other saffron components. We summarize previous evidence and provide original data showing that results obtained both "in vivo" and "in vitro" lead to the same conclusion.
藏红花属于鸢尾科，通常被称为藏红花。不同的文化以及该地区的地理气候特征决定了不同的化学成分，从而形成了最终的产品特征。这就是为什么全面了解这种产品是至关重要的，从这种产品中已经提取出了 150 多种化学物质，但其中只有约三分之一被识别出来。藏红花的化学成分与其应对神经退行性视网膜疾病的功效有关，这方面的研究已经展开。相应地，实验结果为化学成分与神经保护能力之间的严格相关性提供了证据。我们发现，藏红花应对视网膜神经退行性变的能力与以下两点有关：（1）存在特定的藏红花酸；（2）藏红花其他成分的作用。我们总结了之前的证据，并提供了原始数据，表明“体内”和“体外”实验得出的结果是一致的。
