Department of Pediatrics, All India Institute of Medical Sciences, Jodhpur, Rajasthan, 342005, India.
Indian J Pediatr. 2023 Jun;90(6):555-559. doi: 10.1007/s12098-022-04262-5. Epub 2022 Jul 2.
To determine the association between blood eosinophil and neutrophil counts with asthma control.
This retrospective study, conducted in tertiary care hospital of western India, evaluated the hospital electronic medical record (HEMR) of children aged 5 to 18 y who were diagnosed with asthma as per the Global Initiative for Asthma (GINA) guidelines in the pediatric chest clinic (PCC). Eosinophil and neutrophil counts were recorded from HEMR and asthma control was determined as per the GINA guidelines on follow-up.
A total of 742 children attended the PCC in the last 2 y from March 2017 to February 2019; out of which, blood eosinophil and neutrophil counts were done in 116 children with asthma. The median eosinophil and neutrophil count were 0.46 (0.13, 0.78) × 10/L and 5.08 (3.50, 7.53) × 10/L cells, respectively. Eosinophil count was significantly higher in children with well-controlled asthma as compared to partly/uncontrolled asthma [median eosinophil count 0.46 (0.13, 0.78) vs. 0.40 (0.1, 0.66) × 10/L; p = 0.04]; while the neutrophil count was significantly higher in children with partly/uncontrolled asthma as compared to well-controlled asthma [median neutrophil 6.54 (4.32, 7.92) vs. 4.85 (2.96, 6.86) × 10/L; p = 0.04].
High lung function is associated with good asthma control. Although not independently associated, the high absolute eosinophil counts (AEC) is associated with better asthma control, while high absolute neutrophil counts (ANC) is associated with poor asthma control.
确定血嗜酸性粒细胞和中性粒细胞计数与哮喘控制之间的关联。
这是一项在印度西部的三级保健医院进行的回顾性研究，评估了在儿科胸诊所（PCC）根据全球哮喘倡议（GINA）指南诊断为哮喘的 5 至 18 岁儿童的医院电子病历（HEMR）。从 HEMR 中记录嗜酸性粒细胞和中性粒细胞计数，并根据 GINA 指南确定哮喘控制情况。
在 2017 年 3 月至 2019 年 2 月的最后 2 年中，共有 742 名儿童在 PCC 就诊；其中，有 116 名哮喘儿童进行了血嗜酸性粒细胞和中性粒细胞计数。中位嗜酸性粒细胞和中性粒细胞计数分别为 0.46（0.13，0.78）×10/L 和 5.08（3.50，7.53）×10/L。与部分/未控制哮喘相比，控制良好的哮喘患儿的嗜酸性粒细胞计数显著升高[中位数嗜酸性粒细胞计数 0.46（0.13，0.78）比 0.40（0.10，0.66）×10/L；p=0.04]；而部分/未控制哮喘患儿的中性粒细胞计数显著高于控制良好的哮喘患儿[中位数中性粒细胞计数 6.54（4.32，7.92）比 4.85（2.96，6.86）×10/L；p=0.04]。
高肺功能与良好的哮喘控制相关。尽管与哮喘控制无关，但高绝对嗜酸性粒细胞计数（AEC）与更好的哮喘控制相关，而高绝对中性粒细胞计数（ANC）与较差的哮喘控制相关。
