Central Laboratory, The first affiliated hospital of Wannan Medical College, Wuhu, PR China; Key Laboratory of Non-coding RNA Transformation Research of Anhui Higher Education Institutes (Wannan Medical College), Wuhu, PR China.
Clinical laboratory, Suzhou Science and Technology City Hospital Affiliated to Nanjing Medical University, Suzhou, PR China.
Int Immunopharmacol. 2022 Sep;110:108937. doi: 10.1016/j.intimp.2022.108937. Epub 2022 Jun 29.
Innate lymphoid cells (ILCs) and macrophages are tissue-resident cells that play important roles in tissue-immune homeostasis and immune regulation. ILCs are mainly distributed on the barrier surfaces of mammals to ensure immunity or tissue homeostasis following host, microbial, or environmental stimulation. Their complex relationships with different organs enable them to respond quickly to disturbances in environmental conditions and organ homeostasis, such as during infections and tissue damage. Gradually emerging evidence suggests that ILCs also play complex and diverse roles in macrophage development, homeostasis, polarization, inflammation, and viral infection. In turn, macrophages also determine the fate of ILCs to some extent, which indicates that network crossover between these interactions is a key determinant of the immune response. More work is needed to better define the crosstalk of ILCs with macrophages in different tissues and demonstrate how it is affected during inflammation and other diseases. Here, we summarize current research on the functional interactions between ILCs and macrophages and consider the potential therapeutic utility of these interactions for the benefit of human health.
先天淋巴细胞 (ILCs) 和巨噬细胞是组织驻留细胞，它们在组织免疫稳态和免疫调节中发挥重要作用。ILCs 主要分布在哺乳动物的屏障表面，以确保在宿主、微生物或环境刺激后获得免疫力或组织稳态。它们与不同器官的复杂关系使它们能够快速响应环境条件和器官稳态的干扰，例如在感染和组织损伤期间。逐渐出现的证据表明，ILCs 在巨噬细胞的发育、稳态、极化、炎症和病毒感染中也发挥着复杂多样的作用。反过来，巨噬细胞在某种程度上也决定了 ILCs 的命运，这表明这些相互作用之间的网络交叉是免疫反应的关键决定因素。需要做更多的工作来更好地定义 ILCs 和巨噬细胞在不同组织中的相互作用，并证明它们在炎症和其他疾病期间是如何受到影响的。在这里，我们总结了 ILCs 和巨噬细胞之间功能相互作用的当前研究，并考虑了这些相互作用在人类健康中的潜在治疗用途。
