Institute of Biomedical Research, Faculty of Medicine, University of Niš, Nis, Serbia.
Faculty of Biology, University of Belgrade, Belgrade, Serbia.
Hum Cell. 2019 Jul;32(3):231-239. doi: 10.1007/s13577-019-00257-1. Epub 2019 May 11.
Innate lymphoid cells (ILCs) are a recently described group of innate immune cells that mirror the characteristics of CD4 T cell subsets. Based on their transcriptional factor and cytokine profile, ILCs family is divided into main subgroups-ILC1s, ILC2s, and ILC3s. Recently, one new subpopulation of ILCs with immunosuppressive characteristics has been described and named as regulatory ILCs. Various roles of ILCs have been confirmed including the role during the response to microbial signals, the role in inflammation and process of tissue repair. Function of ILCs is mediated through the cytokines production and direct cell-to-cell contact. This article summarizes in detail, the relationship between the ILCs and various immune-related disorders.
先天淋巴细胞（ILCs）是最近描述的一组先天免疫细胞，其特征类似于 CD4 T 细胞亚群。根据其转录因子和细胞因子谱，ILCs 家族分为主要亚群 - ILC1、ILC2 和 ILC3。最近，人们描述了一种具有免疫抑制特征的 ILC 新亚群，并将其命名为调节性 ILCs。已经证实了 ILCs 的各种作用，包括对微生物信号的反应、在炎症和组织修复过程中的作用。ILCs 的功能是通过细胞因子的产生和直接细胞间接触来介导的。本文详细总结了 ILCs 与各种与免疫相关的疾病之间的关系。
