Laboratory of Experimental Research on Gynecology and Obstetrics, Postgraduate Course on Tocogynecology, Botucatu Medical School, Sao Paulo State University (UNESP), Botucatu, São Paulo State, Brazil.
Laboratory of Experimental Research on Gynecology and Obstetrics, Postgraduate Course on Tocogynecology, Botucatu Medical School, Sao Paulo State University (UNESP), Botucatu, São Paulo State, Brazil; Laboratory of System Physiology and Reproductive Toxicology, Institute of Biological and Health Sciences, Federal University of Mato Grosso (UFMT), Barra do Garças, Mato Grosso State, Brazil.
Biochimie. 2022 Oct;201:18-32. doi: 10.1016/j.biochi.2022.06.009. Epub 2022 Jun 30.
The aim of this systematic review and meta-analysis was to analyze the influence of a maternal and/or offspring high-fat diet (HFD) on the morphology of the offspring adipocytes and amount of food and energy consumption. The search was conducted through Pubmed, EMBASE, and Web of Science databases up to October 31st, 2021. The outcomes were extracted and pooled as a standardized mean difference with random effect models. 5,004 articles were found in the databases. Of these, only 31 were selected for this systematic review and 21 were included in the meta-analysis. A large discrepancy in the percentage of fat composing the HFD (from 14% to 62% fat content) was observed. Considering the increase of adipose tissue by hyperplasia (cell number increase) and hypertrophy (cell size increase) in HFD models, the meta-analysis showed that excessive consumption of a maternal HFD influences the development of visceral white adipose tissue in offspring, related to adipocyte hypertrophy, regardless of their HFD or control diet consumption. Upon following a long-term HFD, hyperplasia was confirmed in the offspring. When analyzing the secondary outcome in terms of the amount of food and energy consumed, there was an increase of caloric intake in the offspring fed with HFD whose mothers consumed HFD. Furthermore, the adipocyte hypertrophy in different regions of the adipose tissue is related to the sex of the pups. Thus, the adipose tissue obesity phenotypes in offspring are programmed by maternal consumption of a high-fat diet, independent of postnatal diet.
本系统评价和荟萃分析的目的是分析母体和/或后代高脂肪饮食（HFD）对后代脂肪细胞形态和食物及能量摄入的影响。通过 Pubmed、EMBASE 和 Web of Science 数据库进行了检索，检索截至 2021 年 10 月 31 日。提取结果并采用随机效应模型进行标准化均数差合并。在数据库中发现了 5004 篇文章。其中，只有 31 篇被选入系统评价，21 篇被纳入荟萃分析。观察到 HFD 中脂肪含量的差异很大（从 14%到 62%的脂肪含量）。考虑到 HFD 模型中脂肪组织通过增生（细胞数量增加）和肥大（细胞大小增加）的增加，荟萃分析表明，母体 HFD 的过度摄入会影响后代内脏白色脂肪组织的发育，与脂肪细胞肥大有关，而与他们的 HFD 或对照饮食的消耗无关。长期 HFD 后，在后代中证实了增生。在分析食物和能量消耗的次要结果时，发现母体摄入 HFD 的后代的热量摄入增加。此外，脂肪组织不同区域的脂肪细胞肥大与幼崽的性别有关。因此，后代脂肪组织肥胖表型是由母体高脂肪饮食摄入编程的，与产后饮食无关。
