Post-Graduate Program in Nutrition, Physical Activity and Phenotypic Plasticity, Federal University of Pernambuco, 55608-680 Vitória de Santo Antão, PE, Brazil.
Post-Graduate Program in Nutrition, Physical Activity and Phenotypic Plasticity, Federal University of Pernambuco, 55608-680 Vitória de Santo Antão, PE, Brazil; Department of Nutrition, Federal University of Pernambuco, 50670-901 Recife, PE, Brazil; Nutrition and Phenotypic Plasticity Study Unit, Department of Nutrition, Federal University of Pernambuco, 50670-901 Recife, PE, Brazil.
Life Sci. 2022 Oct 15;307:120880. doi: 10.1016/j.lfs.2022.120880. Epub 2022 Aug 10.
Maternal exposure to a high-fat diet (HFD) during pregnancy and lactation has been related to changes in the hypothalamic circuits involved in the regulation of food intake. Furthermore, maternal HFD during the critical period of development can alter the offspring's metabolic programming with long-term repercussions. This study systematically reviewed the effects of HFD consumption during pre-pregnancy, pregnancy and/or lactation. The main outcomes evaluated were food intake, body weight and cellular or molecular aspects of peptides and hypothalamic receptors involved in the regulation of energy balance in mice. Two independent authors performed a search in the electronic databases Medline/PubMed, LILACS, Web of Science, EMBASE, SCOPUS and Sigle via Open Gray. The experimental studies of mice exposed to HFD during pregnancy and/or lactation that evaluated body composition, food intake, energy expenditure and hypothalamic components related to energy balance were included. Internal validity was assessed using the SYRCLE risk of bias. The Kappa index was measured to analyze the agreement between reviewers. The PRISMA statement was used to report this systematic review. Most studies demonstrated that there was a higher body weight, body fat deposits and food intake, as well as alterations in the expression of hypothalamic neuropeptides in offspring that consumed HFD. Therefore, the maternal diet can affect the phenotype and metabolism of the offspring, in addition to harming the hypothalamic circuits and favoring the orexigenic pathways.
母体在妊娠和哺乳期暴露于高脂肪饮食（HFD）与参与调节摄食的下丘脑回路变化有关。此外，在发育的关键时期母体 HFD 可以改变后代的代谢编程，产生长期影响。本研究系统地综述了妊娠前、妊娠和/或哺乳期 HFD 摄入的影响。评估的主要结果是食物摄入、体重以及参与能量平衡调节的肽和下丘脑受体的细胞或分子方面在小鼠中的变化。两位独立作者在电子数据库 Medline/PubMed、LILACS、Web of Science、EMBASE、SCOPUS 和 Sigle 中通过 Open Gray 进行了搜索。纳入了在妊娠和/或哺乳期暴露于 HFD 的小鼠的实验研究，这些研究评估了身体成分、食物摄入、能量消耗和与能量平衡相关的下丘脑成分。使用 SYRCLE 偏倚风险评估内部有效性。测量 Kappa 指数以分析审稿人之间的一致性。使用 PRISMA 声明报告这项系统综述。大多数研究表明，摄入 HFD 的后代体重、体脂肪沉积和食物摄入增加，以及下丘脑神经肽表达改变。因此，母体饮食会影响后代的表型和代谢，损害下丘脑回路，并促进摄食途径。
