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组织修复策略：从 COVID-19 中学到的关于间充质干细胞治疗的应用。

Tissue repair strategies: What we have learned from COVID-19 in the application of MSCs therapy.

机构信息

Shanghai Institute of Cardiovascular Diseases, Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL 36849, USA.

出版信息

Pharmacol Res. 2022 Aug;182:106334. doi: 10.1016/j.phrs.2022.106334. Epub 2022 Jun 30.

DOI:10.1016/j.phrs.2022.106334
PMID:35779816
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9242686/
Abstract

Coronavirus disease 2019 (COVID-19) infection evokes severe proinflammatory storm and pulmonary infection with the number of confirmed cases (more than 200 million) and mortality (5 million) continue to surge globally. A number of vaccines (e.g., Moderna, Pfizer, Johnson/Janssen and AstraZeneca vaccines) have been developed over the past two years to restrain the rapid spread of COVID-19. However, without much of effective drug therapies, COVID-19 continues to cause multiple irreversible organ injuries and is drawing intensive attention for cell therapy in the management of organ damage in this devastating COVID-19 pandemic. For example, mesenchymal stem cells (MSCs) have exhibited promising results in COVID-19 patients. Preclinical and clinical findings have favored the utility of stem cells in the management of COVID-19-induced adverse outcomes via inhibition of cytokine storm and hyperinflammatory syndrome with coinstantaneous tissue regeneration capacity. In this review, we will discuss the existing data with regards to application of stem cells for COVID-19.

摘要

新型冠状病毒病 2019（COVID-19）感染会引发严重的促炎风暴和肺部感染，全球确诊病例（超过 2 亿例）和死亡率（500 万例）持续飙升。在过去两年中，已经开发出许多疫苗（例如 Moderna、辉瑞、强生/杨森和阿斯利康疫苗）来抑制 COVID-19 的快速传播。然而，由于缺乏有效的药物治疗方法，COVID-19 仍会导致多个不可逆的器官损伤，并引起人们对细胞疗法在管理这种毁灭性的 COVID-19 大流行中的器官损伤方面的关注。例如，间充质干细胞（MSCs）在 COVID-19 患者中显示出有希望的结果。临床前和临床研究结果表明，干细胞通过抑制细胞因子风暴和过度炎症综合征并同时具有组织再生能力，在管理 COVID-19 诱导的不良后果方面具有实用价值。在这篇综述中，我们将讨论有关干细胞在 COVID-19 中的应用的现有数据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6af/9242686/745c280c85fa/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6af/9242686/933df77cbdd5/ga1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6af/9242686/bcf9655b95e0/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6af/9242686/705fa1e671a7/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6af/9242686/745c280c85fa/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6af/9242686/933df77cbdd5/ga1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6af/9242686/bcf9655b95e0/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6af/9242686/705fa1e671a7/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6af/9242686/745c280c85fa/gr3_lrg.jpg

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引用本文的文献

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Hypercholesterolemia Duration and Brain Area Determine Inflammatory Response Intensity and Apoptotic Mediator Activation in Apo E/LDLR Double-Knockout Mice.

Cell Mol Neurobiol. 2025-5-30

[2]
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Neural Regen Res. 2026-3-1

[3]
Astragaloside promotes the secretion of MSC-derived exosomal miR-146a-5p by regulating TRAF6/NF-κB pathway to attenuate inflammation in high glucose-impaired endothelial cells.

In Vitro Cell Dev Biol Anim. 2025-1

[4]
Efficacy and safety of mesenchymal stem cells therapy in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials.

J Transl Med. 2024-6-8

[5]
Stem cell-derived exosomes: emerging therapeutic opportunities for wound healing.

Stem Cell Res Ther. 2023-4-26

本文引用的文献

[1]
COVID-19 and the promise of small molecule therapeutics: Are there lessons to be learnt?

Pharmacol Res. 2022-5

[2]
Adverse effects of remdesivir, hydroxychloroquine and lopinavir/ritonavir when used for COVID-19: systematic review and meta-analysis of randomised trials.

BMJ Open. 2022-3-2

[3]
Mesenchymal Stromal Cells: a Possible Reservoir for HIV-1?

Stem Cell Rev Rep. 2022-4

[4]
Stem Cells Therapy for COVID-19: A Systematic Review and Meta-Analysis.

Front Med (Lausanne). 2021-11-29

[5]
Efficacy and Safety of Mesenchymal Stromal Cells Therapy for COVID-19 Infection: A Systematic Review and Meta-analysis.

Curr Stem Cell Res Ther. 2023

[6]
Development of islet organoids from human induced pluripotent stem cells in a cross-linked collagen scaffold.

Cell Regen. 2021-12-1

[7]
Diverse biological and engineering strategies towards organ regeneration.

Cell Regen. 2021-11-2

[8]
Establishment of porcine and monkey colonic organoids for drug toxicity study.

Cell Regen. 2021-10-2

[9]
Potential Therapeutic Effect of Micrornas in Extracellular Vesicles from Mesenchymal Stem Cells against SARS-CoV-2.

Cells. 2021-9-12

[10]
The Interference between SARS-CoV-2 and Tyrosine Kinase Receptor Signaling in Cancer.

Int J Mol Sci. 2021-5-2

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