Department of Obstetrics and Gynecology National Taiwan University Hospital; No.8, Chung Shan S. Rd., Zhongzheng Dist., Taipei City, 10041, Taiwan, ROC.
Institute of Molecular Medicine, College of Medicine, National Taiwan University; No.7.Chung San South Road, Zhongzheng Dist., Taipei City, 10002, Taiwan, ROC.
Taiwan J Obstet Gynecol. 2022 Jul;61(4):652-656. doi: 10.1016/j.tjog.2022.02.045.
The transcription activator FOXM1 was found to be essential for beta cell expansion and glucose homeostasis during pregnancy in a mouse model. We assumed that the mechanism would be similar in humans. Thus, we aimed to determine the correlation, if any, between FOXM1 and gestational diabetes mellitus in pregnant women.
Participants were recruited and collected from a single tertiary medical center in Taiwan. Participants' maternal peripheral blood was retrieved upon their admission for labor. The postpartum cord blood was harvested within 5 min after delivery of the fetus to test the FOXM1 mRNA expression level, as well as glucose, insulin, and C-peptide protein concentrations.
We recruited 83 pregnant women, 63 without GDM and 20 with GDM. The non-GDM maternal samples had a FOXM1ΔCt of 9.2 ± 1.53, whereas it was 8.92 ± 1.48 in the GDM group (p = 0.504). In the cord blood group, the GDM and non-GDM FOXM1ΔCt were 7.7 ± 1.02 and 7.95 ± 1.56, respectively (p = 0.416).
This is the first study to prove a relationship between FOXM1 and GDM in humans. Although the exact linear correlation is still unknown, our results may provide an impetus for further research.
在小鼠模型中发现转录激活因子 FOXM1 对于妊娠期间β细胞的扩增和葡萄糖内稳态至关重要。我们假设其在人类中的机制也类似。因此，我们旨在确定 FOXM1 与妊娠妇女中妊娠期糖尿病之间是否存在相关性。
参与者从台湾的一家单一的三级医疗中心招募并收集。参与者在分娩时入院时采集母体外周血。胎儿娩出后 5 分钟内采集脐带血，以测试 FOXM1 mRNA 表达水平以及血糖、胰岛素和 C 肽蛋白浓度。
我们招募了 83 名孕妇，其中 63 名无 GDM，20 名患有 GDM。非 GDM 产妇样本的 FOXM1ΔCt 为 9.2±1.53，而 GDM 组为 8.92±1.48（p=0.504）。在脐带血组中，GDM 和非 GDM 的 FOXM1ΔCt 分别为 7.7±1.02 和 7.95±1.56（p=0.416）。
这是第一项证明 FOXM1 与人类 GDM 之间存在关系的研究。尽管确切的线性相关性尚不清楚，但我们的结果可能为进一步研究提供动力。
