Signaling by plant glutamate receptor-like channels: What else!

Plant glutamate receptor-like channels (GLRs) are transmembrane proteins that allow the movement of several ions across membranes. In the model plant Arabidopsis, there are 20 GLR isoforms grouped in three clades and, since their discovery, it was hypothesized that GLRs were mainly involved in signaling processes. Indeed, in the last years, several pieces of evidence demonstrate different signaling roles played by GLRs, related to pollen development, sexual reproduction, chemotaxis, root development, regulation of stomatal aperture, and response to pathogens. Recently, GLRs have gained attention for their role in long-distance electric and calcium signaling. In this review, we resume the evidence about the role of GLRs in signaling processes. This role is mostly linked to the GLRs involvement in the regulation of ion fluxes across membranes and, in particular, of calcium, which represents a key second messenger in plant cell responses to both endogenous and exogenous stimuli.