甜柿宁 C-E，多氧化环己烯，来自甜柿 dunal 及其细胞毒性活性。
Dulcisenes C-E, polyoxygenated cyclohexenes, from Uvaria dulcis dunal and their cytotoxic activity.
机构信息
Laboratory of Natural Products, Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok, 10210, Thailand.
Laboratory of Medicinal Chemistry, Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok, 10210, Thailand; Program in Chemical Sciences, Chulabhorn Graduate Institute, Chulabhorn Royal Academy, Kamphaeng Phet 6 Road, Laksi, Bangkok, 10210, Thailand; Center of Excellence on Environmental Health and Toxicology (EHT), OPS, MHESI, Thailand.
出版信息
Phytochemistry. 2022 Oct;202:113298. doi: 10.1016/j.phytochem.2022.113298. Epub 2022 Jun 30.
Dulcisenes C-E, undescribed polyoxygenated cyclohexenes and twenty-one known compounds were isolated from the dichloromethane extract of the leaves of Uvaria dulcis Dunal. The structures of these undescribed compounds were determined by spectroscopic data analyses, including 1D and 2D NMR, IR, and MS techniques; their absolute configurations were analyzed by NOESY and ECD spectra. Cytotoxicity of sixteen more abundant isolates was evaluated. Cherrevenone and 2',3'-dihydroxy-4',6'-dimethoxychalcone exhibited cytotoxic activity against some cancer cell lines with IC values in the range of 3.3-11.8 μM.
甜果藤 C-E，未描述的多氧化环己烯和二十一种已知化合物从甜果藤叶的二氯甲烷提取物中分离得到。这些未描述的化合物的结构通过包括 1D 和 2D NMR、IR 和 MS 技术在内的光谱数据分析确定；它们的绝对构型通过 NOESY 和 ECD 光谱进行分析。对十六种更丰富的分离物的细胞毒性进行了评估。Cherrevenone 和 2',3'-二羟基-4',6'-二甲氧基查尔酮对一些癌细胞系表现出细胞毒性活性，IC 值范围为 3.3-11.8 μM。
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