Department of Respiratory and Critical Care Medicine, Med-X Center for Manufacturing, Frontiers Science Center for Disease-related Molecular Network, West China Medical School/West China Hospital, Sichuan University, Chengdu, China.
West China Medical School/West China Hospital, Sichuan University, Chengdu, China.
Cancer Lett. 2022 Sep 28;544:215810. doi: 10.1016/j.canlet.2022.215810. Epub 2022 Jun 30.
Lung cancer holds the highest mortality rate among malignancies worldwide. Nevertheless, the potential molecular mechanisms of its tumorigenesis and evolution remain obscure. Circular RNAs (circRNAs), a broad category of covalently closed molecules, follow a malignancy-restricted expression pattern. Leading-edge studies have demonstrated the clinical application prospects of circRNAs in lung cancer. Herein, this review elucidates the biogenesis, biological functions, and pathophysiology of circRNAs. Furthermore, we underscore the forefront of the diagnostic, prognostic, and therapeutic potential of circRNAs in lung cancer as well as discuss the bottleneck that needs to be overcome to translate the basic advances of circRNAs into clinical practice.
肺癌是全球恶性肿瘤死亡率最高的疾病。然而，其肿瘤发生和演进的潜在分子机制仍不清楚。环状 RNA（circRNA）是一类共价闭合的分子，具有严格的组织表达模式。前沿研究表明，circRNA 在肺癌中的临床应用前景广阔。本文阐述了 circRNA 的生物发生、生物学功能和病理生理学。此外，我们强调了 circRNA 在肺癌的诊断、预后和治疗潜力的前沿，讨论了将 circRNA 的基础进展转化为临床实践需要克服的瓶颈。
