环状 RNA 在肺癌中的研究进展。
Research progress of circular RNAs in lung cancer.
机构信息
a Department of thoracic surgery , First Affiliated Hospital of China Medical University , Shenyang , Liaoning , China.
出版信息
Cancer Biol Ther. 2019;20(2):123-129. doi: 10.1080/15384047.2018.1523848. Epub 2018 Nov 7.
Abstract
Lung cancer is one of the most common cancers and the leading cause of cancer-related death worldwide. Despite encouraging results achieved with targeted therapy in recent years, the early diagnosis and treatment of lung cancer remains a major problem. Circular RNA (circRNA), a type of RNA with covalently closed continuous loop structures, has structural stability and certain tissue specificity. Recent studies have found that circRNAs have an important role in tumor development and are expected to be revealed as new targets for tumor prediction and treatment. Research on the biological functions and regulation mechanisms of circRNAs in lung cancer is in its infancy but is gathering momentum. In this review, we discuss the properties, biogenesis, biological function, and research progress of circRNAs in lung cancer to provide a theoretical foundation and new directions for studies on circRNAs in lung cancer.
摘要
肺癌是最常见的癌症之一，也是全球癌症相关死亡的主要原因。尽管近年来靶向治疗取得了令人鼓舞的结果，但肺癌的早期诊断和治疗仍然是一个主要问题。环状 RNA（circRNA）是一种具有共价闭合连续环结构的 RNA，具有结构稳定性和一定的组织特异性。最近的研究发现，circRNAs 在肿瘤的发生发展中具有重要作用，有望成为肿瘤预测和治疗的新靶点。circRNAs 在肺癌中的生物学功能和调控机制的研究还处于起步阶段，但正在逐渐兴起。在这篇综述中，我们讨论了 circRNAs 在肺癌中的特性、生物发生、生物学功能和研究进展，为肺癌中 circRNAs 的研究提供了理论基础和新方向。
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2
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Biochem Biophys Res Commun. 2018 Apr 15;498(4):1009-1015. doi: 10.1016/j.bbrc.2018.03.105. Epub 2018 Mar 16.
3
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