Department of Neurology, Institute of Neurosciences Kolkata, Kolkata, India; Department of Physiology, University of Calcutta, Kolkata, India.
Department of Neurology, Institute of Neurosciences Kolkata, Kolkata, India.
Neurosci Lett. 2022 Aug 24;786:136768. doi: 10.1016/j.neulet.2022.136768. Epub 2022 Jun 30.
The etiopathogenesis of Parkinson's disease (PD) is not clear. Yet, it seems likely that inflammation as well as oxidative stress plays a major role in the disease pathogenesis. Based on our previous findings, we aimed to investigate prospective changes in peripheral inflammasome and oxidative modulators in relation to the progression of motor symptoms and severity of PD.
Levels of inflammatory and oxidative markers in the serum of PD patients and healthy controls were estimated by quantitative ELISA and spectrophotometric methods at the baseline and at the end of one year.
In PD patients, serum NLRP3 inflammasome and IL-1β levels increased significantly over a year, compared to the baseline. The average enzymatic activity of serum SOD1 was also augmented at one-year follow-up. Alongside these serummarker changes, the mean motorseverity of this patient cohort worsened over the time period.
This pioneering study identified a novel association of peripheral inflammatory and oxidative markers with the progression of PD. Correlation of these serum proteins with the central pathological changes in PD and disease severity in a prospective manner might be useful not only for prognostication, but for understanding disease mechanisms and for planning future therapeutic strategies.
帕金森病（PD）的发病机制尚不清楚。然而，炎症和氧化应激似乎在疾病发病机制中起主要作用。基于我们之前的研究结果，我们旨在研究与运动症状进展和 PD 严重程度相关的外周炎性小体和氧化调节剂的前瞻性变化。
通过定量 ELISA 和分光光度法在基线和一年后测量 PD 患者和健康对照组血清中的炎症和氧化标志物水平。
与基线相比，PD 患者的血清 NLRP3 炎性小体和 IL-1β 水平在一年内显著增加。在一年的随访中，血清 SOD1 的平均酶活性也增加了。随着这些血清标志物的变化，该患者队列的平均运动严重程度在一段时间内恶化。
这项开创性的研究确定了外周炎症和氧化标志物与 PD 进展之间的新关联。这些血清蛋白与 PD 中枢病理变化和疾病严重程度的前瞻性相关性不仅有助于预测，还有助于理解疾病机制和规划未来的治疗策略。
