Jandacek R J, Whiteside J A, Holcombe B N, Volpenhein R A, Taulbee J D
Am J Clin Nutr. 1987 May;45(5):940-5. doi: 10.1093/ajcn/45.5.940.
We describe rapid hydrolysis of triglycerides with medium-chain fatty acids in the 1 and 3 positions and a long-chain fatty acid in the 2 position. The triglycerides, 2-linoleoyl-1,3-dioctanoyl glycerol (8L8) and 2-oleoyl-1,3-dioctanoyl glycerol, hydrolyzed more rapidly than triglycerides comprising all long-chain fatty acids. The in vitro hydrolysis rate of 8L8 was similar to that of a medium-chain triglyceride of octanoic and decanoic acids in random positions. From intestinal recovery of 14C 45 min after injection into the isolated, irrigated loop of the small intestine of an anesthetized rat, the amount of 2-[1-14C]linoleoyl-1,3-dioctanoyl glycerol absorbed was greater than 2 1/2 times that of its long-chain analog, 2-[1-14C]linoleoyl-1,3-dioleoyl glycerol. These data support the ease of hydrolysis and absorption of 1,3-dioctanoyl triglycerides with long-chain fatty acids in the 2 position.
我们描述了在1位和3位含有中链脂肪酸且在2位含有长链脂肪酸的甘油三酯的快速水解过程。甘油三酯2-亚油酰基-1,3-二辛酰基甘油（8L8）和2-油酰基-1,3-二辛酰基甘油的水解速度比全部由长链脂肪酸组成的甘油三酯更快。8L8的体外水解速率与随机位置含有辛酸和癸酸的中链甘油三酯的水解速率相似。在麻醉大鼠的离体、灌注小肠肠袢中注射后45分钟，从肠道回收的情况来看，吸收的2-[1-¹⁴C]亚油酰基-1,3-二辛酰基甘油的量比其长链类似物2-[1-¹⁴C]亚油酰基-1,3-二油酰基甘油的量大2.5倍以上。这些数据支持了在2位含有长链脂肪酸的1,3-二辛酰基甘油三酯易于水解和吸收的观点。
