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早产人类婴儿胃脂肪酶的脂肪酸和位置选择性：体外研究

Fatty acid and positional selectivities of gastric lipase from premature human infants: in vitro studies.

作者信息

Jensen R G, deJong F A, Lambert-Davis L G, Hamosh M

机构信息

Department of Nutritional Sciences, University of Connecticut, Storrs 06269-4017.

出版信息

Lipids. 1994 Jun;29(6):433-5. doi: 10.1007/BF02537313.

DOI:10.1007/BF02537313
PMID:8090065
Abstract

Gastric lipase activity in aspirates from premature human infants was tested for fatty acid and positional selectivity using racemic diacid triacylglycerols (TG) as substrates. The resulting free fatty acids and monoacylglycerols (MG) were recovered and analyzed. Octanoic acid (8:0) and decanoic acid (10:0) were hydrolyzed with a preference of 61.5:1 and 2.4:1 compared to palmitic acid (16:0) from rac-16:0-8:0-8:0 and rac-16:0-10:0-10:0, respectively. The ratio of lauric acid (12:0) to oleic acid (18:1) hydrolyzed from rac-18:1-12:0-12:0 was 13:1. Myristic acid (14:0), 18:1 and linoleic acid (18:2) were released at similar rates. These data and the composition of the MG suggest that, in vitro, the lipase is selective for shorter chain fatty acids and for fatty acids on the primary positions of the TG backbone.

摘要

使用外消旋二酸三酰甘油（TG）作为底物，对早产人类婴儿吸出物中的胃脂肪酶活性进行脂肪酸和位置选择性测试。回收并分析生成的游离脂肪酸和单酰甘油（MG）。与来自rac-16:0-8:0-8:0和rac-16:0-10:0-10:0的棕榈酸（16:0）相比，辛酸（8:0）和癸酸（10:0）的水解偏好分别为61.5:1和2.4:1。从rac-18:1-12:0-12:0水解的月桂酸（12:0）与油酸（18:1）的比例为13:1。肉豆蔻酸（14:0）、18:1和亚油酸（18:2）以相似的速率释放。这些数据和MG的组成表明，在体外，脂肪酶对较短链脂肪酸以及TG主链一级位置上的脂肪酸具有选择性。

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本文引用的文献

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