Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.
Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.
J Affect Disord. 2022 Sep 15;313:177-185. doi: 10.1016/j.jad.2022.06.048. Epub 2022 Jun 30.
Previous epidemiological studies revealed inconsistent associations between sugar-sweetened beverage (SSB) consumption and cognitive disorders, but there have been no meta-analyses of the pooled results. Thus, a meta-analysis was performed to determine the association between SSB consumption and cognitive disorders.
A systematic search of the literature prior to May 20, 2022 was performed using the PubMed and Web of Science databases. Random effects models were used to calculate and combine odds ratios (ORs) depending on the degree of heterogeneity.
13 studies met the inclusion criteria. A total of 242,014 participants (2752 in three cross-sectional studies and 239,262 in ten cohort studies) were included. A random effects meta-analysis, according to the comprehensive analysis of SSB consumption, was associated with a greater prevalence of cognitive disorders (OR = 1.17, 95 % CI = 1.05-1.29; I = 90.1 %). Subgroup analyses of study design, type of SSB, or cognitive disorders outcome was performed. In subgroup analyses, we found that SSB intake was associated with a higher prevalence of cognitive disorders in cohort studies, middle-aged and elderly population, and participants with sugar-sweetened soft drinks. However, no significant association was found in other subgroups.
Our results indicate that SSB intake is positively associated with the prevalence of cognitive disorders. Therefore, attention should be paid to reducing SSB intake as an early intervention for cognitive disorders.
先前的流行病学研究表明，含糖饮料（SSB）的摄入与认知障碍之间的关联并不一致，但尚无对汇总结果进行的荟萃分析。因此，进行了荟萃分析以确定 SSB 摄入与认知障碍之间的关联。
在 2022 年 5 月 20 日之前，使用 PubMed 和 Web of Science 数据库对文献进行了系统搜索。根据异质性程度，使用随机效应模型来计算和合并比值比（OR）。
有 13 项研究符合纳入标准。共有 242014 名参与者（三项横断面研究中有 2752 名，十项队列研究中有 239262 名）。根据 SSB 消费的综合分析，随机效应荟萃分析显示与认知障碍的发生率更高相关（OR=1.17，95%CI=1.05-1.29；I=90.1%）。还进行了研究设计、SSB 类型或认知障碍结果的亚组分析。在亚组分析中，我们发现 SSB 摄入与队列研究、中年和老年人群以及含糖软饮料饮用者的认知障碍发生率较高有关。但是，在其他亚组中未发现明显的关联。
我们的结果表明，SSB 摄入与认知障碍的发生率呈正相关。因此，应注意减少 SSB 摄入，将其作为认知障碍的早期干预措施。
