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Beverage consumption and mortality among adults with type 2 diabetes: prospective cohort study.饮料摄入与 2 型糖尿病成人的死亡率：前瞻性队列研究。
BMJ. 2023 Apr 19;381:e073406. doi: 10.1136/bmj-2022-073406.
2
Specific causes of excess late mortality and association with modifiable risk factors among survivors of childhood cancer: a report from the Childhood Cancer Survivor Study cohort.儿童癌症幸存者中晚期死亡过多的具体原因及其与可改变风险因素的关系：来自儿童癌症幸存者研究队列的报告。
Lancet. 2023 Apr 29;401(10386):1447-1457. doi: 10.1016/S0140-6736(22)02471-0. Epub 2023 Apr 5.
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Association of Modifiable Health Conditions and Social Determinants of Health With Late Mortality in Survivors of Childhood Cancer.可改变的健康状况和健康的社会决定因素与儿童癌症幸存者的晚期死亡率的关系。
JAMA Netw Open. 2023 Feb 1;6(2):e2255395. doi: 10.1001/jamanetworkopen.2022.55395.
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High Added Sugars Intake among US Adults: Characteristics, Eating Occasions, and Top Sources, 2015-2018.美国成年人高糖摄入量：特征、摄入场合和主要来源，2015-2018 年。
Nutrients. 2023 Jan 4;15(2):265. doi: 10.3390/nu15020265.
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Premature aging as an accumulation of deficits in young adult survivors of pediatric cancer.儿童癌症幸存者在青年时期出现的过早衰老现象是由于多种缺陷的积累。
J Natl Cancer Inst. 2023 Feb 8;115(2):200-207. doi: 10.1093/jnci/djac209.
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Sugar- and Artificially-Sweetened Beverages and Cancer Mortality in a Large U.S. Prospective Cohort.含糖饮料和人工甜味饮料与美国大型前瞻性队列人群的癌症死亡率。
Cancer Epidemiol Biomarkers Prev. 2022 Oct 4;31(10):1907-1918. doi: 10.1158/1055-9965.EPI-22-0392.
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Trends in added sugars intake and sources among U.S. adults using the National Health and Nutrition Examination Survey (NHANES) 2001-2018.利用2001 - 2018年美国国家健康与营养检查调查（NHANES）分析美国成年人添加糖摄入量及来源的趋势。
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The role of sugar-sweetened beverages in the global epidemics of obesity and chronic diseases.含糖饮料在肥胖和慢性病全球流行中的作用。
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儿童期癌症幸存者成年后与糖和含糖饮料与过早衰老的关系。

Sugar and sugar-sweetened beverages in relation to premature aging in adult survivors of childhood cancer.

机构信息

Division of Public Health Sciences, Department of Surgery; Washington University School of Medicine, St. Louis, MO, USA.

Department of Surgery, Division of Supportive Care in Cancer, University of Rochester Medical Center, James P. Wilmot Cancer Institute, Rochester, NY, USA.

出版信息

Br J Cancer. 2024 Oct;131(7):1169-1177. doi: 10.1038/s41416-024-02815-3. Epub 2024 Aug 8.

DOI:10.1038/s41416-024-02815-3
PMID:39117799
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11442914/
Abstract

BACKGROUND

Premature aging is a significant concern in adult survivors of childhood cancer as they develop aging-related conditions at a younger age than their peers with no history of childhood cancer. Although modifiable lifestyle factors, such as diet, are postulated to affect aging process, supporting evidence is sparse.

METHODS

We examined if the consumption of sugar and sugar-sweetened beverages was related to premature aging in 3322 adult survivors of childhood cancer in the St. Jude Lifetime Cohort. Premature aging was assessed using the Deficit Accumulation Index (DAI) that was a ratio of the number of age-related chronic health conditions each survivor had out of 44 conditions total. Multinomial logistic regressions adjusting for confounders were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs).

RESULTS

There were 46% of childhood cancer survivors consumed SSBs once or more times per day. High intake of sugar, especially sugars added to foods during preparation or processing, and habitual consumption of sugar-sweetened beverage were associated with an increased risk of premature aging.

DISCUSSION

Our findings support a need to include strategies to reduce sugar and sugar-sweetened beverages consumption in lifestyle interventions to promote healthy aging in adult survivors of childhood cancer.

摘要

背景

儿童癌症幸存者成年后会出现与衰老相关的疾病，且发病年龄比没有儿童癌症病史的同龄人更早，因此过早衰老成为他们关注的重要问题。尽管人们推测可改变的生活方式因素（如饮食）会影响衰老过程，但支持这一观点的证据还很缺乏。

方法

我们通过圣裘德儿童癌症长期队列研究，调查了 3322 名成年儿童癌症幸存者的糖和含糖饮料的摄入量是否与过早衰老有关。过早衰老通过缺陷积累指数（DAI）来评估，该指数是每个幸存者出现的 44 种与年龄相关的慢性健康状况数与总状况数的比值。采用多变量逻辑回归模型调整混杂因素，以估计比值比（OR）及其 95%置信区间（CI）。

结果

46%的儿童癌症幸存者每天至少摄入 1 次 SSB。高糖摄入，尤其是在食物准备或加工过程中添加的糖，以及习惯性饮用含糖饮料与过早衰老的风险增加有关。

讨论

我们的研究结果支持在生活方式干预中纳入减少糖和含糖饮料摄入的策略，以促进儿童癌症幸存者的健康衰老。