Wingard D L, Barrett-Connor E
Am J Epidemiol. 1987 Jun;125(6):948-58. doi: 10.1093/oxfordjournals.aje.a114633.
In a prospective population-based study begun in 1972 in Rancho Bernardo, California, the association of cardiovascular disease risk factors, at baseline, with a family history of diabetes and subsequent death from cardiovascular disease was investigated among 3,081 euglycemic, 1,290 borderline hyperglycemic, and 347 diabetic adults between 20 and 79 years of age. The main difference in risk factor distribution was in diabetic men and women 20-49 years of age, of whom those with a family history of diabetes were older and had higher levels of fasting plasma cholesterol and triglyceride. In addition, in all age-sex-diabetes status groups, those with a family history of diabetes included a greater proportion with a family history of heart attack. In five out of 12 groups, the association was statistically significant. Significant independent predictors of cardiovascular disease mortality in euglycemic and borderline hyperglycemic adults were age, sex, cholesterol, and systolic blood pressure, while fasting plasma glucose was a significant predictor in euglycemic adults only. Family history of heart attack was significantly associated with cardiovascular disease mortality in euglycemic and borderline hyperglycemic adults. Family history of diabetes was not significantly associated with mortality risk in any of the three groups, but the risk followed an increasing trend from euglycemic (0.89) to borderline hyperglycemic (1.17) to diabetic (1.31) adults.
在1972年于加利福尼亚州兰乔贝纳多开展的一项基于人群的前瞻性研究中，在3081名血糖正常、1290名血糖临界高值以及347名年龄在20至79岁之间的糖尿病成年患者中，调查了基线时心血管疾病风险因素与糖尿病家族史及随后心血管疾病死亡之间的关联。危险因素分布的主要差异在于20至49岁的糖尿病男性和女性，其中有糖尿病家族史的人年龄更大，空腹血浆胆固醇和甘油三酯水平更高。此外，在所有年龄 - 性别 - 糖尿病状态组中，有糖尿病家族史的人群中心脏病发作家族史的比例更高。在12个组中的5个组中，这种关联具有统计学意义。血糖正常和血糖临界高值成年人中，心血管疾病死亡率的显著独立预测因素是年龄、性别、胆固醇和收缩压，而空腹血糖仅在血糖正常的成年人中是显著预测因素。心脏病发作家族史在血糖正常和血糖临界高值成年人中与心血管疾病死亡率显著相关。糖尿病家族史在三组中的任何一组中与死亡风险均无显著关联，但风险呈现从血糖正常成年人（0.89）到血糖临界高值成年人（1.17）再到糖尿病成年人（1.31）的上升趋势。
