Seira Curto Jofre, Surroca Lopez Amat, Casals Sanchez Maria, Tic Iva, Fernandez Gallegos Maria Rosario, Sanchez de Groot Natalia
Self-organization in Biological Systems Lab, Department of Biochemistry and Molecular Biology, Biosciences Faculty, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.
Front Mol Biosci. 2022 Jun 16;9:926702. doi: 10.3389/fmolb.2022.926702. eCollection 2022.
Our life is closely linked to microorganisms, either through a parasitic or symbiotic relationship. The microbiome contains more than 1,000 different bacterial species and outnumbers human genes by 150 times. Worryingly, during the last 10 years, it has been observed a relationship between alterations in microbiota and neurodegeneration. Several publications support the hypothesis that amyloid structures formed by microorganisms may trigger host proteins aggregation. In this review, we collect pieces of evidence supporting that the crosstalk between human and microbiota amyloid proteins could be feasible and, probably, a more common event than expected before. The combination of their outnumbers, the long periods of time that stay in our bodies, and the widespread presence of amyloid proteins in the bacteria Domain outline a worrying scenario. However, the identification of the exact microorganisms and the mechanisms through with they can influence human disease also opens the door to developing a new and diverse set of therapeutic strategies.
我们的生活与微生物紧密相连，无论是通过寄生还是共生关系。微生物群落包含1000多种不同的细菌物种，其数量比人类基因多150倍。令人担忧的是，在过去10年中，人们观察到微生物群的改变与神经退行性变之间存在关联。一些出版物支持这样的假设，即微生物形成的淀粉样结构可能引发宿主蛋白聚集。在这篇综述中，我们收集了支持人类与微生物群淀粉样蛋白之间相互作用可能可行且可能比预期更常见的证据。它们数量众多、在我们体内停留的时间长以及细菌域中淀粉样蛋白的广泛存在勾勒出了一个令人担忧的场景。然而，确定确切的微生物以及它们影响人类疾病的机制也为开发一系列新的、多样的治疗策略打开了大门。
