Ngah Wan Zurinah Wan, Ahmad Hajar Fauzan, Ankasha Sheril June, Makpol Suzana, Tooyama Ikuo
Medical Innovation Research Center, Shiga University of Medical Science, Otsu 520-2192, Shiga, Japan.
Department of Industrial Biotechnology, Faculty of Industrial Sciences and Technology, Universiti Malaysia Pahang Al-Sultan Abdullah, Gambang 26300, Pahang, Malaysia.
Antioxidants (Basel). 2024 Dec 10;13(12):1504. doi: 10.3390/antiox13121504.
Alzheimer's disease (AD), which is characterized by deterioration in cognitive function and neuronal death, is the most prevalent age-related progressive neurodegenerative disease. Clinical and experimental research has revealed that gut microbiota dysbiosis may be present in AD patients. The changed gut microbiota affects brain function and behavior through several mechanisms, including tau phosphorylation and increased amyloid deposits, neuroinflammation, metabolic abnormalities, and persistent oxidative stress. The lack of effective treatments to halt or reverse the progression of this disease has prompted a search for non-pharmaceutical tools. Modulation of the gut microbiota may be a promising strategy in this regard. This review aims to determine whether specific dietary interventions, particularly antioxidant vitamins, either obtained from the diet or as supplements, may support the formation of beneficial microbiota in order to prevent AD development by contributing to the systemic reduction of chronic inflammation or by acting locally in the gut. Understanding their roles would be beneficial as it may have the potential to be used as a future therapy option for AD patients.
阿尔茨海默病（AD）以认知功能衰退和神经元死亡为特征，是最常见的与年龄相关的进行性神经退行性疾病。临床和实验研究表明，AD患者可能存在肠道微生物群失调。变化的肠道微生物群通过多种机制影响大脑功能和行为，包括tau蛋白磷酸化和淀粉样蛋白沉积增加、神经炎症、代谢异常以及持续的氧化应激。由于缺乏有效的治疗方法来阻止或逆转这种疾病的进展，促使人们寻找非药物手段。调节肠道微生物群可能是这方面一种有前景的策略。本综述旨在确定特定的饮食干预措施，特别是从饮食中获取或作为补充剂的抗氧化维生素，是否可以通过促进全身慢性炎症的减轻或在肠道局部发挥作用，来支持有益微生物群的形成，从而预防AD的发展。了解它们的作用将是有益的，因为这可能有潜力作为AD患者未来的治疗选择。
