Okazaki I, Maruyama K, Kobayashi Y, Lilis R, Suzuki Y
Am J Ind Med. 1987;11(4):439-46. doi: 10.1002/ajim.4700110406.
An assay for type III procollagen peptide (P-III-P) was applied to serum from 80 asbestos insulation workers in order to evaluate its relationship with pulmonary and pleural fibrosis. The serum peptide levels of 16 control workers were 7.8 +/- 2.0 ng/ml (mean +/- SD). An association between the serum values of P-III-P and the profusion of small irregular opacities on chest X-rays was noted. The levels in the group with moderate interstitial pulmonary fibrosis [profusion category 2(2/1, 2/2, and 2/3)] and with marked interstitial pulmonary fibrosis [profusion category 3(3/3)] were 9.9 +/- 2.3 ng/ml (n = 5) and thus tended to be higher than those of 16 control workers (p less than 0.1). On the other hand, there was not correlation between serum peptide levels and pleural lesions nor between the former and duration of asbestos exposure. From the results of the investigation [part I of which is reported elsewhere (Okazaki et al, 1986)] this assay may be useful for detecting individuals with a more marked tendency for progression of interstitial pulmonary fibrosis due to asbestos exposure in insulation work.
为了评估血清III型前胶原肽（P-III-P）与肺和胸膜纤维化的关系，对80名石棉绝缘工人的血清进行了检测。16名对照工人的血清肽水平为7.8±2.0 ng/ml（平均值±标准差）。发现P-III-P的血清值与胸部X线片上小的不规则阴影的密集度之间存在关联。中度间质性肺纤维化组[密集度分类2（2/1、2/2和2/3）]和重度间质性肺纤维化组[密集度分类3（3/3）]的水平分别为9.9±2.3 ng/ml（n = 5），因此往往高于16名对照工人（p<0.1）。另一方面，血清肽水平与胸膜病变之间以及与石棉接触持续时间之间均无相关性。根据本调查结果[其第一部分已在其他地方报道（冈崎等人，1986年）]，该检测方法可能有助于检测出在绝缘工作中因接触石棉而更易发生间质性肺纤维化进展的个体。
