Cavalleri A, Gobba F, Bacchella L, Luberto F, Ziccardi A
Cattedra di Medicina del Lavoro, Università di Modena, Italy.
Br J Ind Med. 1988 Dec;45(12):818-23. doi: 10.1136/oem.45.12.818.
Serum type III procollagen peptide (PIIIP) concentrations were determined in 36 male workers exposed to asbestos fibres in the production of asbestos cement items and in 13 healthy male controls. Mean (SD) PIIIP serum concentrations were 9.3 (1.5) ng/ml (range 7-12) in the controls and 13.7 (3.5)ng/ml (range 7.5-20) in the asbestos workers; the difference was statistically significant (p less than 0.01). The exposed workers were subdivided according to presence or absence of radiological signs of asbestosis and intensity and duration of exposure. PIIIP serum values of workers with asbestos related interstitial fibrosis were the highest of the groups at 14.6 (2.3) ng/ml. In workers with heavy exposure the PIIIP values were significantly related to duration of exposure (r = 0.95; p less than 0.01). PIIIP serum values may be a useful index for the early diagnosis of asbestos induced pulmonary fibrosis and its use should be considered as part of the biological monitoring of exposed workers.
对36名在石棉水泥制品生产中接触石棉纤维的男性工人和13名健康男性对照者测定了血清III型前胶原肽（PIIIP）浓度。对照组的平均（标准差）PIIIP血清浓度为9.3（1.5）ng/ml（范围7 - 12），石棉工人为13.7（3.5）ng/ml（范围7.5 - 20）；差异具有统计学意义（p小于0.01）。根据是否存在石棉肺的放射学征象以及接触强度和持续时间，将接触工人进行了细分。患有石棉相关间质性纤维化的工人的PIIIP血清值在各组中最高，为14.6（2.3）ng/ml。在重度接触工人中，PIIIP值与接触持续时间显著相关（r = 0.95；p小于0.01）。PIIIP血清值可能是石棉所致肺纤维化早期诊断的有用指标，应将其用于作为接触工人生物监测的一部分。
