α-肾上腺素能药物对大鼠中由氟哌啶醇或氟奋乃静诱发的僵住症的影响。
The influence of alpha-adrenergic drugs on catalepsy induced by haloperidol or fluphenazine in rats.
作者信息
Wielosz M, Kleinrok Z, Włoch K, Zebrowska-Lupina I
出版信息
Pol J Pharmacol Pharm. 1978 Sep-Oct;30(5):653-8.
PMID:35783
Abstract
Clonidine (ip) and methoxamine (ivc) inhibit the catalepsy produced by haloperidol or fluphenazine. Naphazoline and xylometazoline antagonize the catalepsy produced by haloperidol, but do not affect significantly that produced by fluphenazine. Phenylephrine did not affect the catalepsy produced by either neuroleptic. The results indicate that drugs stimulating central noradrenergic receptors antagonize the action of compounds blocking the central dopaminergic receptors.
摘要
可乐定（腹腔注射）和甲氧明（静脉注射）可抑制氟哌啶醇或氟奋乃静引起的僵住症。萘甲唑啉和赛洛唑啉可拮抗氟哌啶醇引起的僵住症，但对氟奋乃静引起的僵住症无显著影响。去氧肾上腺素对两种抗精神病药物引起的僵住症均无影响。结果表明，刺激中枢去甲肾上腺素能受体的药物可拮抗阻断中枢多巴胺能受体的化合物的作用。
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