He Yan, Su Yonglin, Zeng Junsong, Chong Weelic, Hu Xiaolin, Zhang Yu, Peng Xingchen
Department of Biotherapy, West China Hospital Sichuan University Chengdu China.
Department of Rehabilitation West China Hospital Sichuan University Chengdu China.
MedComm (2020). 2022 Jun 30;3(3):e145. doi: 10.1002/mco2.145. eCollection 2022 Sep.
Comprehensive understanding of cancer-specific survival differences in gender is critical for cancer prevention and treatment. Based on the Surveillance Epidemiology and End Results database, we included data from the most prevalent cancers (lung, esophageal, liver, pancreatic, stomach, colorectal, kidney, and bladder cancer). Cox proportional hazards regression models were constructed to estimate hazard ratios, simultaneously adjusting for demographic, clinical, and treatment factors. Overall, male patients had a worse cancer-specific survival than female patients. After adjustment for cancer prevalence with 1:1 matching, gender remained a significant factor in cancer-specific survival. Among the included cancer types, female patients showed survival benefit in lung, liver, colorectal, pancreatic, stomach, and esophageal cancer, and male patients showed better survival in bladder cancer. Except for kidney cancer, the gender disparity was consistent between cancer patients with nonmetastatic and metastatic disease. Overall, gender appears to be a significant factor influencing cancer-specific survival, and the prognosis of female patients is better than male patients in most cancers. This work might inspire the development of strategies for gender-specific precision cancer prevention and treatment.
全面了解癌症特异性生存的性别差异对于癌症预防和治疗至关重要。基于监测、流行病学和最终结果数据库，我们纳入了最常见癌症（肺癌、食管癌、肝癌、胰腺癌、胃癌、结直肠癌、肾癌和膀胱癌）的数据。构建Cox比例风险回归模型以估计风险比，同时对人口统计学、临床和治疗因素进行调整。总体而言，男性患者的癌症特异性生存率低于女性患者。在按1:1匹配调整癌症患病率后，性别仍然是癌症特异性生存的一个重要因素。在所纳入的癌症类型中，女性患者在肺癌、肝癌、结直肠癌、胰腺癌、胃癌和食管癌中显示出生存获益，而男性患者在膀胱癌中生存率更高。除肾癌外，非转移性和转移性癌症患者的性别差异一致。总体而言，性别似乎是影响癌症特异性生存的一个重要因素，并且在大多数癌症中女性患者的预后优于男性患者。这项工作可能会激发针对特定性别的精准癌症预防和治疗策略的发展。
