Bezdicek Ondrej, Mana Josef, Růžička Filip, Havlik Filip, Fečíková Anna, Uhrová Tereza, Růžička Evžen, Urgošík Dušan, Jech Robert
Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine and General University Hospital in Prague, Charles University, Prague, Czechia.
Department of Stereotactic and Radiation Neurosurgery, Na Homolce Hospital, Prague, Czechia.
Front Aging Neurosci. 2022 Jun 17;14:886491. doi: 10.3389/fnagi.2022.886491. eCollection 2022.
Everyday functioning and instrumental activities of daily living (IADL) play a vital role in preserving the quality of life in patients with Parkinson's disease (PD) after deep brain stimulation of the subthalamic nucleus (STN-DBS).
The main goal of the current study was to examine IADL change in pre-and post-surgery of the STN-DBS. We also analyzed the influence of the levodopa equivalent daily dose (LEDD) and global cognitive performance (Dementia Rating Scale; DRS-2) as covariates in relation to IADL.
Thirty-two non-demented PD patients were administered before and after STN-DBS neurosurgery the Penn Parkinson's Daily Activities Questionnaire (PDAQ; self-report), the DRS-2 and Beck Depression Inventory (BDI-II) to assess IADL change, global cognition, and depression.
We found a positive effect of STN-DBS on IADL in the post-surgery phase. Moreover, lower global cognition and lower LEDD are predictive of lower IADL in both pre-surgery and post-surgery examinations.
SUMMARY/CONCLUSION: STN-DBS in PD is a safe method for improvement of everyday functioning and IADL. In the post-surgery phase, we show a relation of IADL to the severity of cognitive impairment in PD and to LEDD.
在对帕金森病（PD）患者进行丘脑底核深部脑刺激（STN-DBS）后，日常功能和日常生活工具性活动（IADL）在维持患者生活质量方面起着至关重要的作用。
本研究的主要目的是检查STN-DBS手术前后IADL的变化。我们还分析了左旋多巴等效日剂量（LEDD）和整体认知表现（痴呆评定量表；DRS-2）作为协变量对IADL的影响。
对32例非痴呆型PD患者在STN-DBS神经外科手术前后进行宾夕法尼亚帕金森病日常活动问卷（PDAQ；自我报告）、DRS-2和贝克抑郁量表（BDI-II）评估，以评估IADL变化、整体认知和抑郁情况。
我们发现STN-DBS在术后阶段对IADL有积极影响。此外，在术前和术后检查中，较低的整体认知和较低的LEDD预示着较低的IADL。
总结/结论：PD患者的STN-DBS是改善日常功能和IADL的一种安全方法。在术后阶段，我们显示了IADL与PD认知障碍严重程度和LEDD之间的关系。
