羟钴胺：治疗酒渣鼻潮红和持续性红斑的有效方法。
Hydroxocobalamin: An Effective Treatment for Flushing and Persistent Erythema in Rosacea.
作者信息
Huang Yi-Wei, Huang Hui-Peng, Hsu Chao-Kai, Lee Julia Yu-Yun
机构信息
Dr. Yi-Wei Huang is with the Department of Dermatology at National Taiwan University Hospital in Taipei, Taiwan.
Dr. Hui-Peng Huang is with Huang Hui-Peng Dermatology Clinic in Tainan, Taiwan.
出版信息
J Clin Aesthet Dermatol. 2022 Jun;15(6):42-45.
BACKGROUND
Expression of inducible nitric oxide synthase (NOS) is higher in rosacea skin samples than in normal skin controls. Hydroxocobalamin is a potent inhibitor of all isoforms of NOS, capable of reducing the vasodilatations induced by nitric oxide.
OBJECTIVE
We aimed to evaluate the role of hydroxocobalamin in treating facial flushing and persistent erythema of rosacea.
METHODS
Thirteen patients with rosacea who displayed facial flushing and persistent erythema received 1 to 4 weekly intramuscular injections of hydroxocobalamin 1 to 2 mg. The outcomes were measured using the Clinician's Erythema Assessment (CEA) by photography and an infrared thermometer to evaluate the difference in skin surface temperature (SST) of the cheeks before and after treatment.
RESULTS
Thirty minutes after the first dose of intramuscular injection of hydroxocobalamin, the mean CEA significantly reduced from 2.2± 0.6 to 1.2±0.4 (<0.001), and average SST also significantly reduced from 36.7±0.70°C to 36.2±0.61°C (<0.001) on the cheeks.
CONCLUSION
In our patient sample, intramuscular administration of hydroxocobalamin was effective for immediate reduction of facial erythema associated with rosacea.
背景
酒渣鼻皮肤样本中诱导型一氧化氮合酶（NOS）的表达高于正常皮肤对照。羟钴胺是一种有效的NOS所有同工型抑制剂，能够减少一氧化氮诱导的血管舒张。
目的
我们旨在评估羟钴胺在治疗酒渣鼻面部潮红和持续性红斑中的作用。
方法
13例表现为面部潮红和持续性红斑的酒渣鼻患者，每周接受1至4次1至2毫克羟钴胺的肌肉注射。通过摄影使用临床医师红斑评估（CEA）以及用红外温度计测量治疗前后脸颊皮肤表面温度（SST）的差异来评估结果。
结果
首次肌肉注射羟钴胺30分钟后，脸颊的平均CEA从2.2±0.6显著降至1.2±0.4（<0.001），平均SST也从36.7±0.70°C显著降至36.2±0.61°C（<0.001）。
结论
在我们的患者样本中，肌肉注射羟钴胺可有效立即减轻与酒渣鼻相关的面部红斑。
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