Department of Dermatology, Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 255, sala 3021, 05403-000, São Paulo, Brazil.
Arch Dermatol Res. 2018 Mar;310(2):139-146. doi: 10.1007/s00403-018-1806-z. Epub 2018 Jan 12.
Rosacea is a chronic inflammatory condition with predominant facial involvement. Because of that, many patients sense that rosacea affects quality of life. The etiology of rosacea remains unknown. Recent studies have suggested that aberrant innate immunity is central to this disease. The aim of this study was to examine the presence of Langerhans cells, plasmacytoid dentritic cells (PDC), the expression of Toll-like receptors (TLR) and inducible oxide nitric synthase (iNOS) in skin of patients with rosacea, to highlight the participation of innate immunity in its pathogenesis. 28 biopsy specimens were taken from patients with clinical and histopathological findings of rosacea. Immunohistochemical demonstration of Langerhans cells (anti-CD1a antibody), PDC (anti-CD 123 antibody), TLR2, TLR4 and iNOS was performed in skin samples and compared with normal skin controls. The expression of Langerhans cells was lower in rosacea group than in control group. PDC were found in skin samples of rosacea as isolated cells and forming small clusters. Expression of TLR2, TLR4 and iNOS was higher in rosacea samples than in normal skin controls. This research demonstrates early and late stage components of innate immunity in specimens of rosacea ratifying the existence of an altered innate immunity in its pathogenesis.
酒渣鼻是一种以面部为主的慢性炎症性疾病。正因为如此，许多患者认为酒渣鼻会影响生活质量。酒渣鼻的病因仍不清楚。最近的研究表明，异常的固有免疫是该病的核心。本研究旨在研究酒渣鼻患者皮肤中朗格汉斯细胞、浆细胞样树突状细胞（PDC）、Toll 样受体（TLR）和诱导型一氧化氮合酶（iNOS）的表达，以强调固有免疫在其发病机制中的作用。对 28 例有临床和组织病理学发现的酒渣鼻患者进行活检。对皮肤样本进行朗格汉斯细胞（抗 CD1a 抗体）、PDC（抗 CD123 抗体）、TLR2、TLR4 和 iNOS 的免疫组织化学显示，并与正常皮肤对照进行比较。酒渣鼻组的朗格汉斯细胞表达低于对照组。在酒渣鼻皮肤样本中发现 PDC 呈单个细胞和小簇状存在。TLR2、TLR4 和 iNOS 的表达在酒渣鼻样本中高于正常皮肤对照。这项研究表明在酒渣鼻标本中存在固有免疫的早期和晚期成分，证实了其发病机制中存在异常的固有免疫。
