Sripada Siddharth, Loader Harrison, Kam Man Hei Marcus, Raja Arslan Khaliq, Haggart Joshua, Fawcett Thomas, Peattie Cameron, Molyneux Samuel, Clement Nicholas
University of Edinburgh Medical School, Edinburgh, UK.
Edinburgh Orthopaedics, Royal Infirmary of Edinburgh, Edinburgh, UK.
Adv Orthop. 2022 Jun 24;2022:8146897. doi: 10.1155/2022/8146897. eCollection 2022.
The aims of this study were to assess the health-related quality of life (HRQoL) of patients awaiting anterior cruciate ligament (ACL) reconstruction compared to the population at risk: whether knee-specific function was predictive of HRQoL and to identify factors associated with a worse HRQoL.
Sixty-seven patients (male, = 50; female, = 17; mean age, 29) identified from the surgical waiting list completed a questionnaire that included demographics, BMI, time of injury, EuroQol 5-dimension (EQ-5D), Short-Form (SF-36), and International Knee Documentation Committee (IKDC) scores. Age- and sex-matched HRQoL data were obtained from population level data.
The mean EQ-5D score for the study cohort was significantly worse than the matched score (difference, 0.367; < 0.001), and the same trend was observed for all eight dimensions of the SF-36 score. Thirty-three (49%) patients felt their health, in general, was somewhat or much worse compared to one year ago. There was a correlation between IKDC and EQ-5D scores ( = 0.540, < 0.001). Linear regression was used to formulate the EQ-5D score: EQ-5D = (IKDCx0.013)-0.015 (constant). The SF-36 physical component and length of time on the waiting list were independently associated with the HRQoL, with each 14-point drop or for every 200 days, a clinically significant deterioration in patients' HRQoL occurred, respectively.
Patients had a significantly worse HRQoL when compared to the age- and sex-matched population, which deteriorates with worsening physical function and increasing length of time on the waiting list. The knee-specific IKDC correlated with HRQoL and could be used to estimate the EQ-5D score.
本研究的目的是评估等待前交叉韧带（ACL）重建的患者与有风险人群相比的健康相关生活质量（HRQoL）：膝关节特定功能是否可预测HRQoL，并确定与较差HRQoL相关的因素。
从手术等候名单中确定的67例患者（男性50例；女性17例；平均年龄29岁）完成了一份问卷，内容包括人口统计学、体重指数、受伤时间、欧洲五维健康量表（EQ-5D）、简短健康调查问卷（SF-36）和国际膝关节文献委员会（IKDC）评分。从人群水平数据中获取年龄和性别匹配的HRQoL数据。
研究队列的平均EQ-5D评分显著低于匹配评分（差值为0.367；P<0.001），SF-36评分的所有八个维度也观察到相同趋势。33例（49%）患者感觉总体健康状况与一年前相比有所或大幅变差。IKDC评分与EQ-5D评分之间存在相关性（r=0.540，P<0.001）。采用线性回归来制定EQ-5D评分公式：EQ-5D =（IKDC×0.013）-0.015（常数）。SF-36身体成分评分和等候名单上的时间长度与HRQoL独立相关，每下降至14分或每延长200天，患者的HRQoL就会出现临床上显著的恶化。
与年龄和性别匹配的人群相比，患者的HRQoL显著更差，且随着身体功能恶化和等候名单时间延长而变差。膝关节特定的IKDC评分与HRQoL相关，可用于估计EQ-5D评分。
