Abrams R M, Cooper R J
Am J Obstet Gynecol. 1987 Apr;156(4):1018-23. doi: 10.1016/0002-9378(87)90380-2.
Ketamine hydrochloride was infused intravenously in eight near-term fetal sheep, in doses ranging from 4.6 to 62.2 mg/kg. Local cerebral glucose utilization was determined by the [14C]deoxyglucose method. Heterogeneity in density of autoradiographs, a prominent feature in untreated fetal brains, was greatly diminished in animals receiving greater than 18 mg/kg, with differences between cerebral cortical gray and white matter virtually disappearing at high doses. In striking contrast to the pale, washed-out appearance in autoradiographs of most cerebral, cerebellar, and brain stem structures was a relatively high density of entorhinal cortex, hippocampus, lateral olfactory tract, and olfactory bulbs. Local cerebral glucose utilization of most gray and white matter structures was elevated in one ketamine-treated fetus experiencing a marked drop in PO2 during the study.
对八只近足月胎羊静脉注射盐酸氯胺酮，剂量范围为4.6至62.2毫克/千克。采用[14C]脱氧葡萄糖法测定局部脑葡萄糖利用率。未治疗的胎脑中有一个显著特征，即放射自显影片密度不均一，在接受大于18毫克/千克剂量的动物中，这种不均一性大大降低，在高剂量时大脑皮质灰质和白质之间的差异几乎消失。与大多数大脑、小脑和脑干结构放射自显影片中苍白、暗淡的外观形成鲜明对比的是，内嗅皮质、海马体、外侧嗅束和嗅球的密度相对较高。在研究过程中，一只接受氯胺酮治疗的胎羊出现PO2显著下降，其大多数灰质和白质结构的局部脑葡萄糖利用率升高。
