Abrams R M, Ito M, Frisinger J E, Patlak C S, Pettigrew K D, Kennedy C
Am J Physiol. 1984 Apr;246(4 Pt 2):R608-18. doi: 10.1152/ajpregu.1984.246.4.R608.
The newborn mammalian brain of several species has been shown to have a lower average rate of energy metabolism and a narrower range of rates in its various components than is found in maturity. In a further study of cerebral energy metabolism during development, we have employed the [14C]deoxyglucose method for measuring local cerebral glucose utilization in fetal and neonatal sheep. After establishing the lumped constant to be 0.40 and finding the rate constants for the kinetic behavior of deoxyglucose in plasma and brain to be close to those in other species, we measured the rates of glucose utilization in 44 regions of the brain. The rates were low and homogeneous in midgestation, except for those of brain stem nuclei of the auditory and vestibular systems and those of the hippocampus which were relatively high. In the last 7 wk, local rates rose approximately threefold. After birth there was a further average increase of 50% above full-term levels. The study shows that cerebral energy metabolism rises in most structures during prenatal maturation, a time when sensory stimulation is at a relatively low level and behavioral responses are minimal.
研究表明，与成熟大脑相比，几种新生哺乳动物的大脑平均能量代谢率较低，其各个组成部分的代谢率范围也较窄。在对发育过程中大脑能量代谢的进一步研究中，我们采用了[14C]脱氧葡萄糖法来测量胎儿和新生绵羊的局部脑葡萄糖利用率。在确定集总常数为0.40，并发现脱氧葡萄糖在血浆和大脑中的动力学行为速率常数与其他物种相近后，我们测量了大脑44个区域的葡萄糖利用率。妊娠中期，除听觉和前庭系统的脑干核以及海马体的葡萄糖利用率相对较高外，其他区域的利用率较低且均匀。在妊娠最后7周，局部利用率大约提高了两倍。出生后，平均水平比足月时又进一步提高了50%。该研究表明，在产前成熟期间，大多数结构的大脑能量代谢都会增加，而此时感觉刺激处于相对较低水平，行为反应也最小。
