Abrams R M, Hutchison A A, Jay T M, Sokoloff L, Kennedy C
Department of Obstetrics and Gynecology, University of Florida Health Center, Gainesville.
Brain Res. 1988 May 1;468(1):65-70. doi: 10.1016/0165-3806(88)90008-9.
The [14C]deoxyglucose method for measuring local cerebral glucose utilization was employed in an effort to identify regions of the brain which participate in the increased neuronal activity of rapid eye movement (REM) sleep. The study was conducted in near term fetal sheep in which REM periods are of sufficient duration to obtain reliable data with this method. Neither the postulated executive centers of REM sleep nor those structures in the brainstem known to participate in the electrical activity peculiar to this sleep phase were found to have selectively elevated rates of glucose utilization. Rather, these regions shared equally with virtually all other structures in having rates higher than those which accompany non-REM sleep.
采用[14C]脱氧葡萄糖法测量局部脑葡萄糖利用率，以确定大脑中参与快速眼动（REM）睡眠时神经元活动增强的区域。该研究在近足月胎羊中进行，在胎羊中REM期持续时间足够长，可用此方法获得可靠数据。研究发现，无论是假定的REM睡眠执行中枢，还是脑干中已知参与该睡眠阶段特有电活动的结构，其葡萄糖利用率均未选择性升高。相反，这些区域与几乎所有其他结构一样，其葡萄糖利用率高于非REM睡眠时的水平。
