van der Vange N, Kloosterboer H J, Haspels A A
Am J Obstet Gynecol. 1987 Apr;156(4):918-22. doi: 10.1016/0002-9378(87)90355-3.
The effect of seven low-dose oral contraceptive preparations on carbohydrate metabolism was investigated in groups of 10 healthy volunteers. All preparations contained a similar amount of ethinyl estradiol but differed in the content and type of progestogen. The following progestogens were used: levonorgestrel (monophasic and triphasic), norethisterone (monophasic), cyproterone acetate (monophasic), desogestrel (monophasic and biphasic) and gestodene (triphasic). An oral glucose tolerance test was performed before and after 6 months of treatment; glucose disappearance and insulin response curve were determined. Long-term glucose homeostasis was assessed by the estimation of the extent of glycosylation of plasma proteins and hemoglobin A1. The area under the curve for insulin and glucose did not change during treatment with any of the preparations. In addition the representative variables for long-term glucose control did not increase for any of the preparations during treatment. We conclude from these results that the low-dose pills investigated in this study do not have any adverse effects on glucose metabolism after treatment for 6 months.
在每组10名健康志愿者中研究了7种低剂量口服避孕药制剂对碳水化合物代谢的影响。所有制剂含有的炔雌醇量相似，但孕激素的含量和类型不同。使用了以下孕激素：左炔诺孕酮（单相和三相）、炔诺酮（单相）、醋酸环丙孕酮（单相）、去氧孕烯（单相和双相）和孕二烯酮（三相）。在治疗6个月前后进行口服葡萄糖耐量试验；测定葡萄糖消失和胰岛素反应曲线。通过评估血浆蛋白和血红蛋白A1的糖基化程度来评估长期葡萄糖稳态。在用任何一种制剂治疗期间，胰岛素和葡萄糖曲线下面积均未改变。此外，在治疗期间，任何一种制剂的长期血糖控制代表性变量均未增加。从这些结果我们得出结论，本研究中所研究的低剂量避孕药在治疗6个月后对葡萄糖代谢没有任何不良影响。
