Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Department of Radiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Front Endocrinol (Lausanne). 2022 Jun 16;13:884302. doi: 10.3389/fendo.2022.884302. eCollection 2022.
The association between primary aldosteronism (PA) and lower bone mineral density (BMD) has raised a concern, but the contributing factors remain unclear. We aim to explore the risk factors for lower BMD in PA patients.
We analyzed and compared the data of 60 PA patients with 60 matched essential hypertension (EH) patients. BMD, bone metabolites, and several oxidative stress and inflammation indicators-including C-reactive protein (CRP), superoxide dismutase (SOD), total bilirubin (TBIL), mean platelet volume (MPV), -were assessed and compared in PA and EH patients. Bivariate correlation analysis and multivariate linear regression analysis were performed to explore the factors associated with BMD in PA patients.
The BMD measured by quantitative computed tomography in PA patients was lower than that in EH patients (141.9 ± 34.0 vs. 158.9 ± 55.9 g/cm, = 0.047), especially in patients less than 50 years old. BMD was independently negatively associated with age (standardized = -0.581, < 0.001), serum phosphorus (standardized = -0.203, = 0.008), urinary calcium excretion (standardized = -0.185, = 0.031), and MPV (standardized = -0.172, = 0.043) and positively associated with SOD (standardized = 0.205, = 0.011) and TBIL (standardized = 0.212, = 0.015).
The PA patients showed a lower BMD than the EH patients, which was associated with age, serum phosphorus, urinary calcium excretion, MPV, SOD, and TBIL. These variables might be potential markers for the assessment of bone loss and efficacy of treatments in PA patients.
原发性醛固酮增多症（PA）与较低的骨密度（BMD）之间存在关联，这引起了人们的关注，但导致这种关联的因素仍不清楚。我们旨在探讨 PA 患者 BMD 降低的相关危险因素。
我们分析并比较了 60 例 PA 患者和 60 例匹配的原发性高血压（EH）患者的数据。评估并比较了 PA 和 EH 患者的 BMD、骨代谢物以及几种氧化应激和炎症指标，包括 C 反应蛋白（CRP）、超氧化物歧化酶（SOD）、总胆红素（TBIL）、平均血小板体积（MPV）。采用双变量相关分析和多元线性回归分析探讨与 PA 患者 BMD 相关的因素。
PA 患者定量计算机断层扫描（QCT）测量的 BMD 低于 EH 患者（141.9 ± 34.0 与 158.9 ± 55.9 g/cm³， = 0.047），尤其是年龄小于 50 岁的患者。BMD 与年龄（标准化β = -0.581， < 0.001）、血清磷（标准化β = -0.203， = 0.008）、尿钙排泄量（标准化β = -0.185， = 0.031）和 MPV（标准化β = -0.172， = 0.043）呈负相关，与 SOD（标准化β = 0.205， = 0.011）和 TBIL（标准化β = 0.212， = 0.015）呈正相关。
PA 患者的 BMD 低于 EH 患者，与年龄、血清磷、尿钙排泄量、MPV、SOD 和 TBIL 相关。这些变量可能是评估 PA 患者骨丢失和治疗效果的潜在标志物。
