Lawani Lucky Osaheni, Enebe Joseph Tochukwu, Eze Paul, Igboke Francis Nwabueze, Ukaegbe Chukwuemeka Ikeji, Ugwu Monica Omosivie, Agu Ujunwa Justina, Onyinye Enebe Nympha, Iyoke Chukwuemeka Anthony
Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.
Department of Obstetrics & Gynecology, Federal University Teaching Hospital, Abakaliki, Nigeria.
SAGE Open Med. 2022 Jun 26;10:20503121221105589. doi: 10.1177/20503121221105589. eCollection 2022.
The aim of this study was to determine and compare the occurrence of adverse pregnancy outcomes in a cohort of pregnant women with interpregnancy interval of < and ⩾6 months (short and normal interpregnancy interval, respectively) following a spontaneous miscarriage in their last pregnancies.
This was a cohort study that involved pregnant women with a spontaneous pregnancy loss in their last pregnancies. They were recruited at a gestational age of 13-15 weeks and followed up to determine the obstetric and foetal outcomes of their pregnancies at four tertiary hospitals in Nigeria from July 2018 to September 2019. Data collected were analysed using SPSS version 26.0. A Chi-square and multivariate logistic regression analysis were done, and a p-value of less than 0.05 was assumed to be statistically significant.
A total of 705 participants were studied, out of which 448 (63.5%) and 257 (36.5%) of the participants had short and normal interpregnancy interval after a spontaneous miscarriage. Over 80% of the participants had first-trimester pregnancy losses and were managed with manual vacuum aspiration in 73.3% of the cases. The majority, 87.5% for the normal interpregnancy interval cohort and 86.4% for the short interpregnancy interval cohort, had live births, while 8.5% and 10.1% of the women in the normal and short interpregnancy interval cohorts, respectively, had repeat miscarriages. There was no statistical difference in the occurrence of live births and repeat miscarriages between both cohorts (p > 0.05). There was no increased risk of occurrence of adverse foetomaternal outcomes in both groups (p > 0.05). Multivariate logistic regression analysis showed that there was no statistical difference in the occurrence adverse foetomaternal outcomes between the studied cohorts (p > 0.05).
There was no significant difference in the occurrence of adverse maternal and foetal outcomes in the cohorts of mothers with short and normal interpregnancy interval following miscarriages in their last previous pregnancies.
本研究旨在确定并比较在上次妊娠发生自然流产后，妊娠间隔小于6个月和大于或等于6个月（分别为短妊娠间隔和正常妊娠间隔）的孕妇队列中不良妊娠结局的发生率。
这是一项队列研究，涉及在上次妊娠中发生自然流产的孕妇。她们在孕13 - 15周时入组，并于2018年7月至2019年9月在尼日利亚的四家三级医院进行随访，以确定其妊娠的产科和胎儿结局。收集的数据使用SPSS 26.0版本进行分析。进行了卡方检验和多因素逻辑回归分析，p值小于0.05被认为具有统计学意义。
共研究了705名参与者，其中448名（63.5%）和257名（36.5%）参与者在自然流产后妊娠间隔短和正常。超过80%的参与者在孕早期发生流产，73.3%的病例采用人工负压吸引术处理。大多数人，正常妊娠间隔队列中有87.5%，短妊娠间隔队列中有86.4%活产，而正常和短妊娠间隔队列中分别有8.5%和10.1%的妇女再次流产。两组之间活产和再次流产的发生率无统计学差异（p > 0.05）。两组中不良母胎结局的发生风险均未增加（p > 0.05）。多因素逻辑回归分析显示，所研究队列之间不良母胎结局的发生率无统计学差异（p > 0.05）。
在上次妊娠流产后，妊娠间隔短和正常的母亲队列中，不良母婴结局的发生率无显著差异。
