Department of Oral Pathology, Hospital of Stomatology, Jilin University, Changchun, China.
Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Changchun, China.
Genesis. 2022 Sep;60(8-9):e23491. doi: 10.1002/dvg.23491. Epub 2022 Jul 4.
Periodontal tissues, including gingiva, cementum, periodontal ligament, and alveolar bone, play important roles in oral health. Under physiological conditions, periodontal tissues surround and support the teeth, maintaining the stability of the teeth and distributing the chewing forces. However, under pathological conditions, with the actions of various pathogenic factors, the periodontal tissues gradually undergo some irreversible changes, that is, gingival recession, periodontal ligament rupture, periodontal pocket formation, alveolar bone resorption, eventually leading to the loosening and even loss of the teeth. Currently, the regenerations of the periodontal tissues are still challenging. Therefore, it is necessary to study the development of the periodontal tissues, the principles and processes of which can be used to develop new strategies for the regeneration of periodontal tissues. This review summarizes the development of periodontal tissues and current strategies for periodontal healing and regeneration.
牙周组织包括牙龈、牙骨质、牙周膜和牙槽骨，在口腔健康中发挥着重要作用。在生理条件下，牙周组织环绕并支撑着牙齿，保持牙齿的稳定性并分散咀嚼力。然而，在病理条件下，各种致病因素的作用下，牙周组织逐渐发生一些不可逆转的变化，即牙龈退缩、牙周韧带断裂、牙周袋形成、牙槽骨吸收，最终导致牙齿松动甚至脱落。目前，牙周组织的再生仍然具有挑战性。因此，有必要研究牙周组织的发育，其原理和过程可用于开发牙周组织再生的新策略。本综述总结了牙周组织的发育以及目前牙周愈合和再生的策略。
